3gcz

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[[Image:3gcz.png|left|200px]]
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==Yokose virus Methyltransferase in complex with AdoMet==
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<StructureSection load='3gcz' size='340' side='right' caption='[[3gcz]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3gcz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Yokose_virus Yokose virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GCZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GCZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/mRNA_(nucleoside-2'-O-)-methyltransferase mRNA (nucleoside-2'-O-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.57 2.1.1.57] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gcz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gcz RCSB], [http://www.ebi.ac.uk/pdbsum/3gcz PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gc/3gcz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Presently known flaviviruses belong to three major evolutionary branches: tick-borne viruses, mosquito-borne viruses and viruses with no known vector. Here we present the crystal structure of the Yokose virus methyltransferase at 1.7A resolution, the first structure of a methyltransferase of a Flavivirus with no known vector. Structural comparison of three methyltransferases representative of each of the Flavivirus branches shows that fold and structures are closely conserved, most differences being related to surface loops flexibility. Analysis of the conserved residues throughout all the sequenced flaviviral methyltransferases reveals that, besides the central cleft hosting the substrate and cofactor binding sites, a second, almost continuous, patch is conserved and points away from active site towards the back of the protein. The high level of structural conservation in this region could be functional for the methyltransferase/RNA interaction and stabilization of the ensuing complex.
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{{STRUCTURE_3gcz| PDB=3gcz | SCENE= }}
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Crystal structure of a methyltransferase from a no-known-vector Flavivirus.,Bollati M, Milani M, Mastrangelo E, de Lamballerie X, Canard B, Bolognesi M Biochem Biophys Res Commun. 2009 Apr 24;382(1):200-4. Epub 2009 Mar 9. PMID:19275894<ref>PMID:19275894</ref>
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===Yokose virus Methyltransferase in complex with AdoMet===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19275894}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3gcz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Yokose_virus Yokose virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GCZ OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019275894</ref><references group="xtra"/>
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[[Category: Yokose virus]]
[[Category: Yokose virus]]
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[[Category: Bollati, M.]]
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[[Category: Bollati, M]]
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[[Category: Bolognesi, M.]]
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[[Category: Bolognesi, M]]
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[[Category: Mastrangelo, E.]]
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[[Category: Mastrangelo, E]]
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[[Category: Milani, M.]]
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[[Category: Milani, M]]
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[[Category: SPINE, Structural Proteomics in Europe.]]
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[[Category: SPINE, Structural Proteomics in Europe]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Flavivirus]]
[[Category: Flavivirus]]

Revision as of 10:27, 3 December 2014

Yokose virus Methyltransferase in complex with AdoMet

3gcz, resolution 1.70Å

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