Keithballard/sandbox
From Proteopedia
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==Structure of Class I cytosolic sHSP== | ==Structure of Class I cytosolic sHSP== | ||
| - | < | + | <scene name='60/609774/Dimer_default/2'>Cytosolic CI sHSP from wheat (Ta16.9) shown as a dimer</scene> |
==Introduction== | ==Introduction== | ||
Small heat shock proteins (sHSPs) and related α-crystallins are virtually ubiquitous, ATP-independent molecular chaperones linked to diseases of protein misfolding. They comprise a conserved core α-crystallin domain (ACD) flanked by an evolutionarily variable N-terminal arm (NTA) and semi-conserved C-terminal extension. They are capable of binding up to an equal mass of unfolding protein, forming large, heterogeneous sHSP-substrate complexes that make substrate available to the ATP-dependent chaperones for refolding. | Small heat shock proteins (sHSPs) and related α-crystallins are virtually ubiquitous, ATP-independent molecular chaperones linked to diseases of protein misfolding. They comprise a conserved core α-crystallin domain (ACD) flanked by an evolutionarily variable N-terminal arm (NTA) and semi-conserved C-terminal extension. They are capable of binding up to an equal mass of unfolding protein, forming large, heterogeneous sHSP-substrate complexes that make substrate available to the ATP-dependent chaperones for refolding. | ||
Revision as of 14:34, 3 December 2014
Contents |
Structure of Class I cytosolic sHSP
Introduction
Small heat shock proteins (sHSPs) and related α-crystallins are virtually ubiquitous, ATP-independent molecular chaperones linked to diseases of protein misfolding. They comprise a conserved core α-crystallin domain (ACD) flanked by an evolutionarily variable N-terminal arm (NTA) and semi-conserved C-terminal extension. They are capable of binding up to an equal mass of unfolding protein, forming large, heterogeneous sHSP-substrate complexes that make substrate available to the ATP-dependent chaperones for refolding.
Function
Disease
Relevance
Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
</StructureSection>
