Molecular Playground/E. coli ClpP
From Proteopedia
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[http://www.ncbi.nlm.nih.gov/pubmed/?term=ClpP%3A+A+structurally+dynamic+protease+regulated+by+AAA%2B+proteins 1. ''ClpP: A structurally dynamic protease regulated by AAA+ proteins.'' Alexopoulos JA ''et. al'' (2012 J Struct Bio)] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=ClpP%3A+A+structurally+dynamic+protease+regulated+by+AAA%2B+proteins 1. ''ClpP: A structurally dynamic protease regulated by AAA+ proteins.'' Alexopoulos JA ''et. al'' (2012 J Struct Bio)] | ||
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[http://www.ncbi.nlm.nih.gov/pubmed/?term=ClpA+and+ClpX+ATPases+bind+simultaneously+to+opposite+ends+of+ClpP+peptidase+to+form+active+hybrid+complexes 2.''ClpA and ClpX ATPases bind simultaneously to opposite ends of ClpP peptidase to form active hybrid complexes.'' Ortega J ''et. al'' (2004 J. Struct Biol.) | [http://www.ncbi.nlm.nih.gov/pubmed/?term=ClpA+and+ClpX+ATPases+bind+simultaneously+to+opposite+ends+of+ClpP+peptidase+to+form+active+hybrid+complexes 2.''ClpA and ClpX ATPases bind simultaneously to opposite ends of ClpP peptidase to form active hybrid complexes.'' Ortega J ''et. al'' (2004 J. Struct Biol.) | ||
== Acknowledgements== | == Acknowledgements== | ||
Kamal Joshi, Joanne Lau, Jing Liu, Rob Vass | Kamal Joshi, Joanne Lau, Jing Liu, Rob Vass |
Revision as of 20:18, 3 December 2014
Here in the Chien lab, we study how proteolysis plays a large part in protein quality control. The maintenance and timely destruction of protein levels plays an important role during cell homeostasis and cell transitions/differentiation, yet much of what governs these processes has yet to be fully understood.
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References
[http://www.ncbi.nlm.nih.gov/pubmed/?term=ClpA+and+ClpX+ATPases+bind+simultaneously+to+opposite+ends+of+ClpP+peptidase+to+form+active+hybrid+complexes 2.ClpA and ClpX ATPases bind simultaneously to opposite ends of ClpP peptidase to form active hybrid complexes. Ortega J et. al (2004 J. Struct Biol.)
Acknowledgements
Kamal Joshi, Joanne Lau, Jing Liu, Rob Vass