Porphobilinogen synthase
From Proteopedia
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===3D structures of porphobilinogen synthase=== | ===3D structures of porphobilinogen synthase=== | ||
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| - | + | *Porphobilinogen synthase | |
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| - | + | **[[1aw5]] – yPBS (mutant) + Zn – yeast<br /> | |
| + | **[[1qml]] - yPBS + Hg<br /> | ||
| + | **[[1qnv]] - yPBS + Pb<br /> | ||
| + | **[[1pv8]] – hPBS (mutant) – human<br /> | ||
| + | **[[2z0i]], [[2z1b]] - PBS - mouse<br /> | ||
| + | **[[1w54]], [[1w56]], [[1w5m]], [[1w5n]], [[1w5o]], [[1w5p]], [[1w5q]] - PaPBS (mutant) + Mg + Zn – ''Pseudomonas aeruginosa'' | ||
| - | + | *Porphobilinogen synthase complex | |
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| + | **[[1b4k]] - PaPBS + LA + Zn<br /> | ||
| + | **[[1b4e]] - EcPBS + LA + Zn – ''Escherichia coli''<br /> | ||
| + | **[[1ylv]], [[1h7n]] - yPBS + LA + Zn<br /> | ||
| + | **[[1w31]] - yPBS + LA derivative + Zn<br /> | ||
| + | **[[1h7o]] - yPBS + ALA + Zn<br /> | ||
| + | **[[1h7r]], [[1h7p]], [[1eb3]], [[1gjp]] - yPBS + inhibitor + Zn<br /> | ||
| + | **[[1ohl]] - yPBS + intermediate + Zn<br /> | ||
| + | **[[1i8j]], [[1l6s]], [[1l6y]] - EcPBS + inhibitor + Mg + Zn<br /> | ||
| + | **[[2c1h]] - PBS + inhibitor + Mg – ''Chlorobium vibrioforme'' <br /> | ||
| + | **[[2c13]], [[2c14]] - PaPBS (mutant) + inhibitor + Mg<br /> | ||
| + | **[[2c15]], [[2c16]], [[2c18]], [[2c19]] - PaPBS + inhibitor + Mg<br /> | ||
| + | **[[1e51]] - hPBS + PBG + Zn<br /> | ||
| + | **[[1gzg]] - PaPBS + LA derivative + Mg<br /> | ||
| + | **[[2woq]] - PaPBS + antibiotic + Mg<br /> | ||
| + | **[[1w1z]] - PBS + LA + Mg – ''Prosthecochloris vibrioformis'' | ||
| + | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 07:25, 4 December 2014
Porphobilinogen synthase (PBS) catalyzes the formation of porphobilinogen (PBG) from 2 molecules of aminolevulinic acid (ALA). PBS participates in porphyrin biosynthesis. Levulinic acid (LA) is an inhibitor of PBS. Porphyrin is the precursor of hemes, chlorophyll and vitamin B12. PBS deficiency can be caused by lead and other heavy metal poisoning.
3D structures of porphobilinogen synthase
Updated on 04-December-2014
