Proteinase

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* '''PRO A''' is a carboxylproteinase.<br />
* '''PRO A''' is a carboxylproteinase.<br />
* '''PRO K''' is a serine protease which cleaves proteins preferentially after hydrophobic residues. Calcium ions contribute to the stability of the enzyme. PRO K is active over a wide pH range and is used in molecular biology to inactivate nucleases from preparations of DNA or RNA. PRO K is used in the partial proteolysis of lactoferrin into its N- and C-lobe. The two lobes of lactoferrin have different antimicrobial and antifungal properties. PRO K can digest hair (keratin).
* '''PRO K''' is a serine protease which cleaves proteins preferentially after hydrophobic residues. Calcium ions contribute to the stability of the enzyme. PRO K is active over a wide pH range and is used in molecular biology to inactivate nucleases from preparations of DNA or RNA. PRO K is used in the partial proteolysis of lactoferrin into its N- and C-lobe. The two lobes of lactoferrin have different antimicrobial and antifungal properties. PRO K can digest hair (keratin).
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</StructureSection>
==3D structures of proteinase==
==3D structures of proteinase==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===PRO A===
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*'''Proteinase A'''
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[[2sga]] – SgPRO – ''Streptomyces griseus''<br />
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**[[2sga]] – SgPRO – ''Streptomyces griseus''<br />
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[[2jxr]], [[1fmu]], [[1fmx]] – yPRO - yeast<br />
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**[[2jxr]], [[1fmu]], [[1fmx]] – yPRO - yeast<br />
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[[1sgc]] - SgPRO + chymostatin A<br />
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**[[1sgc]] - SgPRO + chymostatin A<br />
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[[3sga]], [[4sga]], [[5sga]] - SgPRO + polypeptide inhibitor<br />
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**[[3sga]], [[4sga]], [[5sga]] - SgPRO + polypeptide inhibitor<br />
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[[1dp5]], [[1dpj]], [[1g0v]] - yPRO + polypeptide inhibitor IA3<br />
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**[[1dp5]], [[1dpj]], [[1g0v]] - yPRO + polypeptide inhibitor IA3<br />
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[[1fq5]] - yPRO + inhibitor
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**[[1fq5]] - yPRO + inhibitor
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===PRO B===
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*'''Proteinase B'''
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[[3sgb]] – SgPRO + turkey ovomucoid inhibitor<br />
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**[[3sgb]] – SgPRO + turkey ovomucoid inhibitor<br />
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[[1sgp]], [[1sgq]], [[1sgr]], [[1cso]], [[1ct0]], [[1ct2]], [[1ct4]], [[1ds2]], [[2sgp]], [[2nu3]], [[2nu4]] – SgPRO + turkey ovomucoid inhibitor (mutant)<br />
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**[[1sgp]], [[1sgq]], [[1sgr]], [[1cso]], [[1ct0]], [[1ct2]], [[1ct4]], [[1ds2]], [[2sgp]], [[2nu3]], [[2nu4]] – SgPRO + turkey ovomucoid inhibitor (mutant)<br />
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[[4sgb]] - SgPRO + potato inhibitor
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**[[4sgb]] - SgPRO + potato inhibitor
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===PRO K===
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*'''Proteinase K'''
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[[2prk]], [[1cnm]], [[1egq]], [[2id8]], [[2g4v]], [[2v8b]], [[3gt3]], [[3gt4]], [[3d9q]], [[3ddz]], [[3de0]] , [[3de1]], [[3de2]], [[3de3]], [[3de4]], [[3de5]], [[3de6]], [[3de7]], [[3dvq]], [[3dvr]], [[3dvs]], [[3dw1]], [[3dw3]], [[3dwe]], [[3i2y]], [[3i30]], [[3i37]], [[3i34]], [[3l1k]], [[3aj8]], [[3aj9]], [[3q40]], [[3q5g]], [[3qmp]], [[4b5l]], [[4fon]] – EaPRO + Ca – ''Engyodontium album'' <br />
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**[[2prk]], [[1cnm]], [[1egq]], [[2id8]], [[2g4v]], [[2v8b]], [[3gt3]], [[3gt4]], [[3d9q]], [[3ddz]], [[3de0]] , [[3de1]], [[3de2]], [[3de3]], [[3de4]], [[3de5]], [[3de6]], [[3de7]], [[3dvq]], [[3dvr]], [[3dvs]], [[3dw1]], [[3dw3]], [[3dwe]], [[3i2y]], [[3i30]], [[3i37]], [[3i34]], [[3l1k]], [[3aj8]], [[3aj9]], [[3q40]], [[3q5g]], [[3qmp]], [[4b5l]], [[4fon]] – EaPRO + Ca – ''Engyodontium album'' <br />
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[[1ic6]] – EaPRO (mutant) + Ca <br />
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**[[1ic6]] – EaPRO (mutant) + Ca <br />
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[[1ptk]], [[1ht3]] – EaPRO + Ca + Hg <br />
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**[[1ptk]], [[1ht3]] – EaPRO + Ca + Hg <br />
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[[2pkc]] – EaPRO + Na <br />
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**[[2pkc]] – EaPRO + Na <br />
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[[4dj5]] – EaPRO <br />
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**[[4dj5]] – EaPRO <br />
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''PRO K complex with peptide''
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*Proteinase K complex with peptide
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[[3prk]], [[1p7v]], [[1p7w]] – EaPRO + Ca + peptide inhibitor <br />
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**[[3prk]], [[1p7v]], [[1p7w]] – EaPRO + Ca + peptide inhibitor <br />
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[[1bjr]], [[2dqk]], [[2duj]] – EaPRO + Ca + lactoferrin peptide <br />
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**[[1bjr]], [[2dqk]], [[2duj]] – EaPRO + Ca + lactoferrin peptide <br />
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[[2hd4]] – EaPRO + Ca + lactoferrin peptide inhibitor<br />
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**[[2hd4]] – EaPRO + Ca + lactoferrin peptide inhibitor<br />
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[[2dp4]], [[3ptl]] – EaPRO + lactoferrin peptide <br />
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**[[2dp4]], [[3ptl]] – EaPRO + lactoferrin peptide <br />
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[[1pek]], [[1pfg]] – EaPRO + peptide inhibitor <br />
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**[[1pek]], [[1pfg]] – EaPRO + peptide inhibitor <br />
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[[1pj8]] – EaPRO + Hg + substrate analog peptide <br />
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**[[1pj8]] – EaPRO + Hg + substrate analog peptide <br />
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[[2hpz]], [[2pq2]] – EaPRO + Ca + peptide <br />
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**[[2hpz]], [[2pq2]] – EaPRO + Ca + peptide <br />
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[[3osz]] – EaPRO + Ca + antimicrobial peptide <br />
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**[[3osz]] – EaPRO + Ca + antimicrobial peptide <br />
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[[2b6n]] – PRO + tripeptide - ''Serratia''<br />
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**[[2b6n]] – PRO + tripeptide - ''Serratia''<br />
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''PRO K complex with small molecule''
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*Proteinase K complex with small molecule
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[[2pwb]] – EaPRO + Ca + coumarin <br />
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**[[2pwb]] – EaPRO + Ca + coumarin <br />
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[[2pyz]] – EaPRO + Ca + auramine <br />
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**[[2pyz]] – EaPRO + Ca + auramine <br />
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[[2pwa]] – EaPRO + Ca + alanine boronic acid <br />
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**[[2pwa]] – EaPRO + Ca + alanine boronic acid <br />
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[[1oyo]] – EaPRO + Ca + melanin monomer <br />
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**[[1oyo]] – EaPRO + Ca + melanin monomer <br />
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[[3dyb]] – EaPRO + Ca + digalacturonic acid <br />
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**[[3dyb]] – EaPRO + Ca + digalacturonic acid <br />
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===PRO 3C===
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*'''Proteinase 3C'''
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[[1qa7]] – PRO – Hepatitis virus<br />
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**[[1qa7]] – PRO – Hepatitis virus<br />
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[[2vb0]] - PRO – Coxsakievirus
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**[[2vb0]] - PRO – Coxsakievirus
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===H2-PRO===
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*'''H2-Proteinase'''
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[[1wni]] – PRO – ''Trimeresurus flavoviridis''
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**[[1wni]] – PRO – ''Trimeresurus flavoviridis''
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===Aspartic PRO===
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*'''Aspartic Proteinase'''
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[[2asi]] – PRO – ''Rhizomucor miehei''<br />
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**[[2asi]] – PRO – ''Rhizomucor miehei''<br />
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[[1zap]] – CaPRO – ''Candida albicans''<br />
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**[[1zap]] – CaPRO – ''Candida albicans''<br />
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[[1izd]] - AoPRO – ''Aspergillus oryzae''<br />
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**[[1izd]] - AoPRO – ''Aspergillus oryzae''<br />
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[[1eag]] – CaPRO + inhibitor <br />
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**[[1eag]] – CaPRO + inhibitor <br />
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[[1fq4]] - yPRO + inhibitor<br />
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**[[1fq4]] - yPRO + inhibitor<br />
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[[1j71]] - PRO + polypeptide inhibitor – ''Candida tropicalis''<br />
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**[[1j71]] - PRO + polypeptide inhibitor – ''Candida tropicalis''<br />
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[[1ize]] - AoPRO + polypeptide-statin inhibitor<br />
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**[[1ize]] - AoPRO + polypeptide-statin inhibitor<br />
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[[1wkr]] - PRO + polypeptide-statin inhibitor – ''Irpex lacteus''
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**[[1wkr]] - PRO + polypeptide-statin inhibitor – ''Irpex lacteus''
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===Cysteine PRO===
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*'''Cysteine Proteinase'''
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[[2hrv]] – PRO 2A – human rhinovirus
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**[[2hrv]] – PRO 2A – human rhinovirus
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===Serine PRO===
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*'''Serine Proteinase'''
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[[1s2n]], [[1sh7]] – PRO – ''Vibrio''<br />
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**[[1s2n]], [[1sh7]] – PRO – ''Vibrio''<br />
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[[3s9a]], [[3s9b]] – RvPRO – Siamese Russell’s viper<br />
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**[[3s9a]], [[3s9b]] – RvPRO – Siamese Russell’s viper<br />
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[[3s9c]], [[3sbk]] – RvPRO + human factor V polypeptide<br />
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**[[3s9c]], [[3sbk]] – RvPRO + human factor V polypeptide<br />
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[[1ga1]], [[1ga4]], [[1ga6]], [[1nlu]] – PsPRO + iodotyrostatin fragment – ''Pseudomonas''<br />
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**[[1ga1]], [[1ga4]], [[1ga6]], [[1nlu]] – PsPRO + iodotyrostatin fragment – ''Pseudomonas''<br />
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[[1kdv]], [[1kdy]], [[1kdz]], [[1ke1]], [[1ke2]] - PsPRO + polypeptide inhibitor
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**[[1kdv]], [[1kdy]], [[1kdz]], [[1ke1]], [[1ke2]] - PsPRO + polypeptide inhibitor
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}}
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</StructureSection>
 
== References ==
== References ==
<references/>
<references/>
[[Category: Topic Page]]
[[Category: Topic Page]]

Revision as of 11:27, 4 December 2014

E. coli proteinase K (grey) complex with lactoferrin peptide (green) and Ca+2 (green) and nitrate ions (PDB code 2duj)

Drag the structure with the mouse to rotate

3D structures of proteinase

Updated on 04-December-2014

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky, Karsten Theis

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