Pteridine reductase
From Proteopedia
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'''Pteridine reductase''' (PTR) catalyzes the reduction of 5,6,7,8-tetrahydrobiopterin (THBP) to biopterin. PTR is part of pterin and folate metabolism. NADP is the hydrogen acceptor in this reduction. PTR is essential for growth of trypanosomatid protozoans like Leishmania parasites, thus PTR inhibitors like methotrexate (MTX) or triaminoquinazoline (TAQ) are tested as potential drugs. | '''Pteridine reductase''' (PTR) catalyzes the reduction of 5,6,7,8-tetrahydrobiopterin (THBP) to biopterin. PTR is part of pterin and folate metabolism. NADP is the hydrogen acceptor in this reduction. PTR is essential for growth of trypanosomatid protozoans like Leishmania parasites, thus PTR inhibitors like methotrexate (MTX) or triaminoquinazoline (TAQ) are tested as potential drugs. | ||
| + | </StructureSection> | ||
==3D structures of pteridine reductase== | ==3D structures of pteridine reductase== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *'''Pteridine reductase''' | |
| - | [[2xox]] – LdPTR1 (mutant) – ''Leishmania donovani'' <BR /> | + | **[[2xox]] – LdPTR1 (mutant) – ''Leishmania donovani'' <BR /> |
| - | [[2bfo]] – LmPTR1 + NADPH – ''Leishmania major'' <BR /> | + | **[[2bfo]] – LmPTR1 + NADPH – ''Leishmania major'' <BR /> |
| - | + | *Pteridine reductase complex with inhibitor | |
| - | + | **[[1w0c]] – LmPTR1 + NADPH + TAQ <BR /> | |
| - | [[1w0c]] – LmPTR1 + NADPH + TAQ <BR /> | + | **[[1p33]] – PTR1 + NADPH + MTX – ''Leishmania tarentolae''<BR /> |
| - | [[1p33]] – PTR1 + NADPH + MTX – ''Leishmania tarentolae''<BR /> | + | **[[1mxf]] – TcPTR2 + NADPH + MTX – ''Trypanosoma cruzi''<BR /> |
| - | [[1mxf]] – TcPTR2 + NADPH + MTX – ''Trypanosoma cruzi''<BR /> | + | **[[2c7v]] – TbPTR1 + NADPH + MTX – ''Trypanosoma brucei''<BR /> |
| - | [[2c7v]] – TbPTR1 + NADPH + MTX – ''Trypanosoma brucei''<BR /> | + | **[[3bmn]], [[3bmo]], [[3bmq]], [[2wd7]], [[2wd8]], [[2vz0]], [[3jq6]], [[3jq7]], [[3jq8]], [[3jq9]], [[3jqa]], [[3jqb]], [[3jqc]], [[3jqf]], [[3jqd]], [[3jqe]], [[3jqg]], [[3gn1]], [[3gn2]], [[3mcv]], [[2x9g]], [[2x9v]], [[2x9n]], [[2yhi]], [[2yhu]] – TbPTR1 + NADPH + inhibitor <BR /> |
| - | [[3bmn]], [[3bmo]], [[3bmq]], [[2wd7]], [[2wd8]], [[2vz0]], [[3jq6]], [[3jq7]], [[3jq8]], [[3jq9]], [[3jqa]], [[3jqb]], [[3jqc]], [[3jqf]], [[3jqd]], [[3jqe]], [[3jqg]], [[3gn1]], [[3gn2]], [[3mcv]], [[2x9g]], [[2x9v]], [[2x9n]], [[2yhi]], [[2yhu]] – TbPTR1 + NADPH + inhibitor <BR /> | + | **[[2bfa]], [[2bfm]], [[3h4v]] – LmPTR1 + NADPH + inhibitor <BR /> |
| - | [[2bfa]], [[2bfm]], [[3h4v]] – LmPTR1 + NADPH + inhibitor <BR /> | + | |
| - | + | *Pteridine reductase complex with ligand | |
| - | [[2bfp]] – LmPTR1 + NADPH + THBP <BR /> | + | **[[2bfp]] – LmPTR1 + NADPH + THBP <BR /> |
| - | [[2qhx]] – LmPTR1 + NADPH + ligand<BR /> | + | **[[2qhx]] – LmPTR1 + NADPH + ligand<BR /> |
| - | [[1e92]], [[2bf7]] – LmPTR1 + NADPH + DHBP <BR /> | + | **[[1e92]], [[2bf7]] – LmPTR1 + NADPH + DHBP <BR /> |
| - | [[1mxh]] – TcPTR1 + NADPH + folate <BR /> | + | **[[1mxh]] – TcPTR1 + NADPH + folate <BR /> |
| - | [[3bmc]] – TbPTR1 + NADPH + folate <BR /> | + | **[[3bmc]] – TbPTR1 + NADPH + folate <BR /> |
| + | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:33, 4 December 2014
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3D structures of pteridine reductase
Updated on 04-December-2014
