1mk2

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[[Image:1mk2.gif|left|200px]]<br /><applet load="1mk2" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1mk2.gif|left|200px]]
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caption="1mk2, resolution 2.74&Aring;" />
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'''SMAD3 SBD complex'''<br />
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{{Structure
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|PDB= 1mk2 |SIZE=350|CAPTION= <scene name='initialview01'>1mk2</scene>, resolution 2.74&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''SMAD3 SBD complex'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1MK2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MK2 OCA].
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1MK2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MK2 OCA].
==Reference==
==Reference==
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Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control., Qin BY, Lam SS, Correia JJ, Lin K, Genes Dev. 2002 Aug 1;16(15):1950-63. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12154125 12154125]
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Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control., Qin BY, Lam SS, Correia JJ, Lin K, Genes Dev. 2002 Aug 1;16(15):1950-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12154125 12154125]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: smad3]]
[[Category: smad3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:56:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:44:21 2008''

Revision as of 10:44, 20 March 2008

Image:1mk2.gif


PDB ID 1mk2

Drag the structure with the mouse to rotate
, resolution 2.74Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



SMAD3 SBD complex


Contents

Overview

Smad3 transduces the signals of TGF-betas, coupling transmembrane receptor kinase activation to transcriptional control. The membrane-associated molecule SARA (Smad Anchor for Receptor Activation) recruits Smad3 for phosphorylation by the receptor kinase. Upon phosphorylation, Smad3 dissociates from SARA and enters the nucleus, in which its transcriptional activity can be repressed by Ski. Here, we show that SARA and Ski recognize specifically the monomeric and trimeric forms of Smad3, respectively. Thus, trimerization of Smad3, induced by phosphorylation, simultaneously activates the TGF-beta signal by driving Smad3 dissociation from SARA and sets up the negative feedback mechanism by Ski. Structural models of the Smad3/SARA/receptor kinase complex and Smad3/Ski complex provide insights into the molecular basis of regulation.

Disease

Known diseases associated with this structure: Anderson disease OMIM:[607690], Chylomicron retention disease OMIM:[607690], Mowat-Wilson syndrome OMIM:[605802]

About this Structure

1MK2 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control., Qin BY, Lam SS, Correia JJ, Lin K, Genes Dev. 2002 Aug 1;16(15):1950-63. PMID:12154125

Page seeded by OCA on Thu Mar 20 12:44:21 2008

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