Pyruvate dehydrogenase kinase

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===PDK isozyme 1===
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*PDK isozyme 1
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[[2q8f ]]– hPDK1 – human<br />
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**[[2q8f ]]– hPDK1 – human<br />
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[[2q8g]] – hPDK1 + drug<br />
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**[[2q8g]] – hPDK1 + drug<br />
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[[2q8h]] – hPDK1 + dichloro-acetic acid
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**[[2q8h]] – hPDK1 + dichloro-acetic acid
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===PDK isozyme 2===
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*PDK isozyme 2
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[[1jm6]] – PDK2 + ADP – rat<br />
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**[[1jm6]] – PDK2 + ADP – rat<br />
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[[2btz]] – hPDK2 <br />
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**[[2btz]] – hPDK2 <br />
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[[2bu2]] – hPDK2 + benzonitrile derivative + ATP<br />
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**[[2bu2]] – hPDK2 + benzonitrile derivative + ATP<br />
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[[2bu5]] - hPDK2 + benzonitrile derivative<br />
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**[[2bu5]] - hPDK2 + benzonitrile derivative<br />
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[[2bu6]] - hPDK2 + propanamide derivative<br />
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**[[2bu6]] - hPDK2 + propanamide derivative<br />
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[[2bu7]] - hPDK2 + acetamide derivative<br />
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**[[2bu7]] - hPDK2 + acetamide derivative<br />
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[[2bu8]] - hPDK2 + dichloro-acetic acid + ADP<BR />
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**[[2bu8]] - hPDK2 + dichloro-acetic acid + ADP<BR />
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[[4mp2]], [[4mp7]], [[4mpc]], [[4mpe]], [[4mpn]] – hPDK2 + inhibitor<br />
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**[[4mp2]], [[4mp7]], [[4mpc]], [[4mpe]], [[4mpn]] – hPDK2 + inhibitor<br />
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[[3crk]], [[3crl]] – hPDK2 + acetyltransferase component of pyruvate dehydrogenase complex
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**[[3crk]], [[3crl]] – hPDK2 + acetyltransferase component of pyruvate dehydrogenase complex
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===PDK isozyme 3===
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*PDK isozyme 3
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[[1y8n]], [[1y8o]], [[1y8p]], [[2pnr]] – hPDK3 + acetyltransferase component of pyruvate dehydrogenase complex <br />
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**[[1y8n]], [[1y8o]], [[1y8p]], [[2pnr]] – hPDK3 + acetyltransferase component of pyruvate dehydrogenase complex <br />
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[[2q8i]] – hPDK3 + radicicol
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**[[2q8i]] – hPDK3 + radicicol
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===PDK isozyme 4===
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*PDK isozyme 4
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[[2e0a]] – hPDK4 + AMPPNP<br />
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[[2zkj]], [[3d2r]] – hPDK4 + ADP<BR />
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[[2zdx]], [[2zdy]] – hPDK4 (mutant) + inhibitor
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**[[2e0a]] – hPDK4 + AMPPNP<br />
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**[[2zkj]], [[3d2r]] – hPDK4 + ADP<BR />
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**[[2zdx]], [[2zdy]] – hPDK4 (mutant) + inhibitor
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[[Category: Topic Page]]
[[Category: Topic Page]]

Revision as of 09:25, 7 December 2014

Template:STRUCTURE 1jm6

Pyruvate dehydrogenase kinase (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites.

3D structures of pyruvate dehydrogenase kinase

Updated on 07-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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