1mky
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1mky.jpg|left|200px]] | + | [[Image:1mky.jpg|left|200px]] |
| - | + | ||
| - | '''Structural Analysis of the Domain Interactions in Der, a Switch Protein Containing Two GTPase Domains''' | + | {{Structure |
| + | |PDB= 1mky |SIZE=350|CAPTION= <scene name='initialview01'>1mky</scene>, resolution 1.90Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> and <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Structural Analysis of the Domain Interactions in Der, a Switch Protein Containing Two GTPase Domains''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1MKY is a [ | + | 1MKY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MKY OCA]. |
==Reference== | ==Reference== | ||
| - | Domain arrangement of Der, a switch protein containing two GTPase domains., Robinson VL, Hwang J, Fox E, Inouye M, Stock AM, Structure. 2002 Dec;10(12):1649-58. PMID:[http:// | + | Domain arrangement of Der, a switch protein containing two GTPase domains., Robinson VL, Hwang J, Fox E, Inouye M, Stock AM, Structure. 2002 Dec;10(12):1649-58. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12467572 12467572] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Thermotoga maritima]] | [[Category: Thermotoga maritima]] | ||
| Line 24: | Line 33: | ||
[[Category: gtpase]] | [[Category: gtpase]] | ||
[[Category: kh-domain]] | [[Category: kh-domain]] | ||
| - | [[Category: tandem g- | + | [[Category: tandem g-domain]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:44:44 2008'' |
Revision as of 10:44, 20 March 2008
| |||||||
| , resolution 1.90Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structural Analysis of the Domain Interactions in Der, a Switch Protein Containing Two GTPase Domains
Overview
The EngA subfamily of essential bacterial GTPases has a unique domain structure consisting of two adjacent GTPase domains (GD1 and GD2) and a C-terminal domain. The structure of Thermotoga maritima Der bound to GDP determined at 1.9 A resolution reveals a novel domain arrangement in which the GTPase domains pack at either side of the C-terminal domain. Unexpectedly, the C-terminal domain resembles a KH domain, missing the distinctive RNA recognition elements. Conserved motifs of the nucleotide binding site of GD1 are integral parts of the GD1-KH domain interface, suggesting the interactions between these two domains are directly influenced by the GTP/GDP cycling of the protein. In contrast, the GD2-KH domain interface is distal to the GDP binding site of GD2.
About this Structure
1MKY is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.
Reference
Domain arrangement of Der, a switch protein containing two GTPase domains., Robinson VL, Hwang J, Fox E, Inouye M, Stock AM, Structure. 2002 Dec;10(12):1649-58. PMID:12467572
Page seeded by OCA on Thu Mar 20 12:44:44 2008
Categories: Single protein | Thermotoga maritima | Fox, E. | Hwang, J. | Inouye, M. | Robinson, V L. | Stock, A M. | GDP | PO4 | Der | Enga | Gtpase | Kh-domain | Tandem g-domain
