1mm0
From Proteopedia
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| - | [[Image:1mm0.gif|left|200px]] | + | [[Image:1mm0.gif|left|200px]] |
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| - | '''Solution structure of termicin, an antimicrobial peptide from the termite Pseudacanthotermes spiniger''' | + | {{Structure |
| + | |PDB= 1mm0 |SIZE=350|CAPTION= <scene name='initialview01'>1mm0</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Solution structure of termicin, an antimicrobial peptide from the termite Pseudacanthotermes spiniger''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1MM0 is a [ | + | 1MM0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudacanthotermes_spiniger Pseudacanthotermes spiniger]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MM0 OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of termicin, an antimicrobial peptide from the termite Pseudacanthotermes spiniger., Da Silva P, Jouvensal L, Lamberty M, Bulet P, Caille A, Vovelle F, Protein Sci. 2003 Mar;12(3):438-46. PMID:[http:// | + | Solution structure of termicin, an antimicrobial peptide from the termite Pseudacanthotermes spiniger., Da Silva P, Jouvensal L, Lamberty M, Bulet P, Caille A, Vovelle F, Protein Sci. 2003 Mar;12(3):438-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12592014 12592014] |
[[Category: Pseudacanthotermes spiniger]] | [[Category: Pseudacanthotermes spiniger]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: termite]] | [[Category: termite]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:45:05 2008'' |
Revision as of 10:45, 20 March 2008
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Solution structure of termicin, an antimicrobial peptide from the termite Pseudacanthotermes spiniger
Overview
The solution structure of termicin from hemocytes of the termite Pseudacanthotermes spiniger was determined by proton two-dimensional nuclear magnetic resonance spectroscopy and molecular modeling techniques. Termicin is a cysteine-rich antifungal peptide also exhibiting a weak antibacterial activity. The global fold of termicin consists of an alpha-helical segment (Phe4-Gln14) and a two-stranded (Phe19-Asp25 and Gln28-Phe33) antiparallel beta-sheet forming a "cysteine stabilized alphabeta motif" (CSalphabeta) also found in antibacterial and antifungal defensins from insects and from plants. Interestingly, termicin shares more structural similarities with the antibacterial insect defensins and with MGD-1, a mussel defensin, than with the insect antifungal defensins such as drosomycin and heliomicin. These structural comparisons suggest that global fold alone does not explain the difference between antifungals and antibacterials. The antifungal properties of termicin may be related to its marked hydrophobicity and its amphipatic structure as compared to the antibacterial defensins. [SWISS-PROT accession number: Termicin (P82321); PDB accession number: 1MM0.]
About this Structure
1MM0 is a Single protein structure of sequence from Pseudacanthotermes spiniger. Full crystallographic information is available from OCA.
Reference
Solution structure of termicin, an antimicrobial peptide from the termite Pseudacanthotermes spiniger., Da Silva P, Jouvensal L, Lamberty M, Bulet P, Caille A, Vovelle F, Protein Sci. 2003 Mar;12(3):438-46. PMID:12592014
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