1mmj
From Proteopedia
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| - | [[Image:1mmj.gif|left|200px]] | + | [[Image:1mmj.gif|left|200px]] |
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| - | '''Porcine pancreatic elastase complexed with a potent peptidyl inhibitor, FR136706''' | + | {{Structure |
| + | |PDB= 1mmj |SIZE=350|CAPTION= <scene name='initialview01'>1mmj</scene>, resolution 2.2Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=FR1:2-[4-[[(S)-1-[[(S)-2-[[(RS)-3,3,3-TRIFLUORO-1-ISOPROPYL-2-OXOPROPYL]AMINOCARBONYL]PYRROLIDIN-1-YL-]CARBONYL]-2-METHYLPROPYL]AMINOCARBONYL]BENZOYLAMINO]ACETIC ACID'>FR1</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Porcine pancreatic elastase complexed with a potent peptidyl inhibitor, FR136706''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1MMJ is a [ | + | 1MMJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MMJ OCA]. |
==Reference== | ==Reference== | ||
| - | True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor., Kinoshita T, Nakanishi I, Sato A, Tada T, Bioorg Med Chem Lett. 2003 Jan 6;13(1):21-4. PMID:[http:// | + | True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor., Kinoshita T, Nakanishi I, Sato A, Tada T, Bioorg Med Chem Lett. 2003 Jan 6;13(1):21-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12467609 12467609] |
[[Category: Pancreatic elastase]] | [[Category: Pancreatic elastase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: chymotrypsin family]] | [[Category: chymotrypsin family]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:45:22 2008'' |
Revision as of 10:45, 20 March 2008
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| , resolution 2.2Å | |||||||
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| Ligands: | , and | ||||||
| Activity: | Pancreatic elastase, with EC number 3.4.21.36 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Porcine pancreatic elastase complexed with a potent peptidyl inhibitor, FR136706
Overview
The crystal structure of porcine pancreatic elastase (PPE) complexed with a potent peptidyl inhibitor, FR136706, was solved at 2.2A resolution. FR136706 fits snugly into the extended active site pocket. The benzene moiety of FR136706 induced dramatic movement of the side chain moiety of Arg217 and both moieties formed a pi-pi interaction, which has never been found previously in structures of PPE complexed with inhibitors. This novel interaction mode may lead to design of new types of inhibitors.
About this Structure
1MMJ is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.
Reference
True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor., Kinoshita T, Nakanishi I, Sato A, Tada T, Bioorg Med Chem Lett. 2003 Jan 6;13(1):21-4. PMID:12467609
Page seeded by OCA on Thu Mar 20 12:45:22 2008
