2y39
From Proteopedia
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| - | [[ | + | ==NI-BOUND FORM OF CUPRIAVIDUS METALLIDURANS CH34 CNRXS== |
| + | <StructureSection load='2y39' size='340' side='right' caption='[[2y39]], [[Resolution|resolution]] 1.41Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2y39]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cupriavidus_metallidurans Cupriavidus metallidurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y39 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2y3g|2y3g]], [[2y3h|2y3h]], [[2y3b|2y3b]], [[2y3d|2y3d]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y39 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y39 RCSB], [http://www.ebi.ac.uk/pdbsum/2y39 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | CnrX is the metal sensor and signal modulator of the three-protein transmembrane signal transduction complex CnrYXH of Cupriavidus metallidurans CH34 that is involved in the setup of cnr (cobalt and nickel resistance). We have determined the atomic structure of the soluble domain of CnrX in its Ni-bound, Co-bound, or Zn-bound form. Ni and Co ions elicit a biological response, while the Zn-bound form is inactive. The structures presented here reveal the topology of intraprotomer and interprotomer interactions and the ability of metal-binding sites to fine-tune the packing of CnrX dimer as a function of the bound metal. These data suggest an allosteric mechanism to explain how the complex is switched on and how the signal is modulated by Ni or Co binding. These results provide clues to propose a model for signal propagation through the membrane in the complex. | ||
| - | + | Structural Basis for Metal Sensing by CnrX.,Trepreau J, Girard E, Maillard AP, de Rosny E, Petit-Haertlein I, Kahn R, Coves J J Mol Biol. 2011 Mar 21. PMID:21414325<ref>PMID:21414325</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | == | + | |
| - | < | + | |
[[Category: Cupriavidus metallidurans]] | [[Category: Cupriavidus metallidurans]] | ||
| - | [[Category: Coves, J | + | [[Category: Coves, J]] |
| - | [[Category: Girard, E | + | [[Category: Girard, E]] |
| - | [[Category: Kahn, R | + | [[Category: Kahn, R]] |
| - | [[Category: Maillard, A P | + | [[Category: Maillard, A P]] |
| - | [[Category: Petit-Haertlein, I | + | [[Category: Petit-Haertlein, I]] |
| - | [[Category: Rosny, E De | + | [[Category: Rosny, E De]] |
| - | [[Category: Trepreau, J | + | [[Category: Trepreau, J]] |
[[Category: Metal binding protein]] | [[Category: Metal binding protein]] | ||
Revision as of 08:59, 8 December 2014
NI-BOUND FORM OF CUPRIAVIDUS METALLIDURANS CH34 CNRXS
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