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1mom
From Proteopedia
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| - | [[Image:1mom.jpg|left|200px]] | + | [[Image:1mom.jpg|left|200px]] |
| - | + | ||
| - | '''CRYSTAL STRUCTURE OF MOMORDIN, A TYPE I RIBOSOME INACTIVATING PROTEIN FROM THE SEEDS OF MOMORDICA CHARANTIA''' | + | {{Structure |
| + | |PDB= 1mom |SIZE=350|CAPTION= <scene name='initialview01'>1mom</scene>, resolution 2.16Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''CRYSTAL STRUCTURE OF MOMORDIN, A TYPE I RIBOSOME INACTIVATING PROTEIN FROM THE SEEDS OF MOMORDICA CHARANTIA''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1MOM is a [ | + | 1MOM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MOM OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of momordin, a type I ribosome inactivating protein from the seeds of Momordica charantia., Husain J, Tickle IJ, Wood SP, FEBS Lett. 1994 Apr 4;342(2):154-8. PMID:[http:// | + | Crystal structure of momordin, a type I ribosome inactivating protein from the seeds of Momordica charantia., Husain J, Tickle IJ, Wood SP, FEBS Lett. 1994 Apr 4;342(2):154-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8143869 8143869] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: rRNA N-glycosylase]] | [[Category: rRNA N-glycosylase]] | ||
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[[Category: protein synthesis inhibitor(toxin)]] | [[Category: protein synthesis inhibitor(toxin)]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:46:12 2008'' |
Revision as of 10:46, 20 March 2008
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| , resolution 2.16Å | |||||||
|---|---|---|---|---|---|---|---|
| Activity: | rRNA N-glycosylase, with EC number 3.2.2.22 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF MOMORDIN, A TYPE I RIBOSOME INACTIVATING PROTEIN FROM THE SEEDS OF MOMORDICA CHARANTIA
Overview
A type I ribosome-inactivating protein, extracted and purified from M. charantia seeds, was crystallised by vapour diffusion with polyethylene glycol at pH 7.2. X-ray data were collected to 2.1 A resolution and the structure solved by molecular replacement using the A-chain coordinates of ricin. The overall fold of the protein is similar to ricin but there are differences in secondary structure, on the surface and in the active site cleft. These differences are probably due in part to the evolution of the protein without a B-chain partner. The most extensive reorganisation occurs at the C-terminus whereas Tyr70 shows the greatest change in the active site cleft.
About this Structure
1MOM is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Crystal structure of momordin, a type I ribosome inactivating protein from the seeds of Momordica charantia., Husain J, Tickle IJ, Wood SP, FEBS Lett. 1994 Apr 4;342(2):154-8. PMID:8143869
Page seeded by OCA on Thu Mar 20 12:46:12 2008
