1mpv
From Proteopedia
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| - | [[Image:1mpv.gif|left|200px]] | + | [[Image:1mpv.gif|left|200px]] |
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| - | '''Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide''' | + | {{Structure |
| + | |PDB= 1mpv |SIZE=350|CAPTION= <scene name='initialview01'>1mpv</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene> and <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1MPV is a [ | + | 1MPV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPV OCA]. |
==Reference== | ==Reference== | ||
| - | BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2., Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM, Immunity. 2002 Oct;17(4):515-24. PMID:[http:// | + | BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2., Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM, Immunity. 2002 Oct;17(4):515-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12387744 12387744] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Cochran, A G.]] | [[Category: Cochran, A G.]] | ||
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[[Category: beta-hairpin]] | [[Category: beta-hairpin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:46:36 2008'' |
Revision as of 10:46, 20 March 2008
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide
Overview
The TNF-like ligand BAFF/BLyS is a potent survival factor for B cells. It binds three receptors: TACI, BCMA, and BR3. We show that BR3 signaling promotes processing of the transcription factor NF-kappaB2/p100 to p52. NF-kappaB2/p100 cleavage was abrogated in B cells from A/WySnJ mice possessing a mutant BR3 gene, but not in TACI or BCMA null B cells. Furthermore, wild-type mice injected with BAFF-neutralizing BR3-Fc protein showed reduced basal NF-kappaB2 activation. BR3-Fc treatment of NZB/WF1 mice, which develop a fatal lupus-like syndrome, inhibited NF-kappaB2 processing and attenuated the disease process. Since inhibiting the BR3-BAFF interaction has therapeutic ramifications, the ligand binding interface of BR3 was investigated and found to reside within a 26 residue core domain. When stabilized within a structured beta-hairpin peptide, six of these residues were sufficient to confer binding to BAFF.
About this Structure
1MPV is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2., Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM, Immunity. 2002 Oct;17(4):515-24. PMID:12387744
Page seeded by OCA on Thu Mar 20 12:46:36 2008
Categories: Single protein | Cochran, A G. | Dixit, V M. | French, D M. | Gordon, N C. | Grewal, I S. | Kayagaki, N. | Lee, W. | Seshasayee, D. | Starovasnik, M A. | Wang, H. | Yan, M. | Yin, J. | ACE | NH2 | Beta-hairpin
