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1mq0

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[[Image:1mq0.gif|left|200px]]<br /><applet load="1mq0" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1mq0.gif|left|200px]]
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caption="1mq0, resolution 2.40&Aring;" />
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'''Crystal Structure of Human Cytidine Deaminase'''<br />
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{{Structure
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|PDB= 1mq0 |SIZE=350|CAPTION= <scene name='initialview01'>1mq0</scene>, resolution 2.40&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=BRD:1-BETA-RIBOFURANOSYL-1,3-DIAZEPINONE'>BRD</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Cytidine_deaminase Cytidine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.5 3.5.4.5]
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|GENE=
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}}
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'''Crystal Structure of Human Cytidine Deaminase'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1MQ0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=BRD:'>BRD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cytidine_deaminase Cytidine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.5 3.5.4.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQ0 OCA].
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1MQ0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQ0 OCA].
==Reference==
==Reference==
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Structure of human cytidine deaminase bound to a potent inhibitor., Chung SJ, Fromme JC, Verdine GL, J Med Chem. 2005 Feb 10;48(3):658-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15689149 15689149]
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Structure of human cytidine deaminase bound to a potent inhibitor., Chung SJ, Fromme JC, Verdine GL, J Med Chem. 2005 Feb 10;48(3):658-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15689149 15689149]
[[Category: Cytidine deaminase]]
[[Category: Cytidine deaminase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: zinc]]
[[Category: zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:57:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:46:46 2008''

Revision as of 10:46, 20 March 2008

Image:1mq0.gif


PDB ID 1mq0

Drag the structure with the mouse to rotate
, resolution 2.40Å
Ligands: and
Activity: Cytidine deaminase, with EC number 3.5.4.5
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Human Cytidine Deaminase


Contents

Overview

Human cytidine deaminase (CDA) is an enzyme prominent for its role in catalyzing metabolic processing of nucleoside-type anticancer and antiviral agents. It is thus a promising target for the development of small molecule therapeutic adjuvants. We report the first crystal structure of human CDA as a complex with a tight-binding inhibitor, diazepinone riboside 1. The structure reveals that inhibitor 1 is able to establish a canonical pi/pi-interaction with a key active site residue, Phe 137.

Disease

Known disease associated with this structure: Anemia, congenital dyserythropoietic, type I OMIM:[607465]

About this Structure

1MQ0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human cytidine deaminase bound to a potent inhibitor., Chung SJ, Fromme JC, Verdine GL, J Med Chem. 2005 Feb 10;48(3):658-60. PMID:15689149

Page seeded by OCA on Thu Mar 20 12:46:46 2008

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