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3h98
From Proteopedia
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| - | [[ | + | ==Crystal structure of HCV NS5b 1b with (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyrimidine derivative== |
| + | <StructureSection load='3h98' size='340' side='right' caption='[[3h98]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3h98]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H98 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H98 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B5P:N-{3-[5-HYDROXY-8-(3-METHYLBUTYL)-7-OXO-7,8-DIHYDROIMIDAZO[1,2-A]PYRIMIDIN-6-YL]-1,1-DIOXIDO-4H-1,2,4-BENZOTHIADIAZIN-7-YL}METHANESULFONAMIDE'>B5P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h98 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h98 RCSB], [http://www.ebi.ac.uk/pdbsum/3h98 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | (1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives have been investigated as potential anti-HCV drugs. Their synthesis, HCV NS5B polymerase inhibition, and replicon activity are discussed. | ||
| - | + | HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives.,Wang G, Lei H, Wang X, Das D, Hong J, Mackinnon CH, Coulter TS, Montalbetti CA, Mears R, Gai X, Bailey SE, Ruhrmund D, Hooi L, Misialek S, Rajagopalan PT, Cheng RK, Barker JJ, Felicetti B, Schonfeld DL, Stoycheva A, Buckman BO, Kossen K, Seiwert SD, Beigelman L Bioorg Med Chem Lett. 2009 Aug 1;19(15):4480-3. Epub 2009 May 9. PMID:19500983<ref>PMID:19500983</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[RNA polymerase|RNA polymerase]] | *[[RNA polymerase|RNA polymerase]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: RNA-directed RNA polymerase]] | [[Category: RNA-directed RNA polymerase]] | ||
[[Category: Viruses]] | [[Category: Viruses]] | ||
| - | [[Category: Bailey, S | + | [[Category: Bailey, S]] |
| - | [[Category: Barker, J L | + | [[Category: Barker, J L]] |
| - | [[Category: Beigelmana, L | + | [[Category: Beigelmana, L]] |
| - | [[Category: Buckman, B | + | [[Category: Buckman, B]] |
| - | [[Category: Cheng, R K.Y | + | [[Category: Cheng, R K.Y]] |
| - | [[Category: Das, D | + | [[Category: Das, D]] |
| - | [[Category: Felicetti, B | + | [[Category: Felicetti, B]] |
| - | [[Category: Gai, X | + | [[Category: Gai, X]] |
| - | [[Category: Hooi, L | + | [[Category: Hooi, L]] |
| - | [[Category: Kossen, K | + | [[Category: Kossen, K]] |
| - | [[Category: Lei, H | + | [[Category: Lei, H]] |
| - | [[Category: Mackinnon, C | + | [[Category: Mackinnon, C]] |
| - | [[Category: Mears, R | + | [[Category: Mears, R]] |
| - | [[Category: Misialek, S | + | [[Category: Misialek, S]] |
| - | [[Category: Montalbetti, C A.G | + | [[Category: Montalbetti, C A.G]] |
| - | [[Category: Rajagopalan, R | + | [[Category: Rajagopalan, R]] |
| - | [[Category: Ruhrmund, D | + | [[Category: Ruhrmund, D]] |
| - | [[Category: Seiwert, S | + | [[Category: Seiwert, S]] |
| - | [[Category: Stoycheva, A | + | [[Category: Stoycheva, A]] |
| - | [[Category: Wang, G | + | [[Category: Wang, G]] |
| - | [[Category: Wang, X | + | [[Category: Wang, X]] |
[[Category: Nucleotide binding]] | [[Category: Nucleotide binding]] | ||
[[Category: Rna polymerase]] | [[Category: Rna polymerase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 09:15, 8 December 2014
Crystal structure of HCV NS5b 1b with (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyrimidine derivative
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Categories: RNA-directed RNA polymerase | Viruses | Bailey, S | Barker, J L | Beigelmana, L | Buckman, B | Cheng, R K.Y | Das, D | Felicetti, B | Gai, X | Hooi, L | Kossen, K | Lei, H | Mackinnon, C | Mears, R | Misialek, S | Montalbetti, C A.G | Rajagopalan, R | Ruhrmund, D | Seiwert, S | Stoycheva, A | Wang, G | Wang, X | Nucleotide binding | Rna polymerase | Transferase
