1mr3

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[[Image:1mr3.gif|left|200px]]<br /><applet load="1mr3" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1mr3.gif|left|200px]]
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caption="1mr3, resolution 1.60&Aring;" />
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'''Saccharomyces cerevisiae ADP-ribosylation Factor 2 (ScArf2) complexed with GDP-3'P at 1.6A resolution'''<br />
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{{Structure
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|PDB= 1mr3 |SIZE=350|CAPTION= <scene name='initialview01'>1mr3</scene>, resolution 1.60&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=G3D:GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE'>G3D</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene> and <scene name='pdbligand=PDO:1,3-PROPANDIOL'>PDO</scene>
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|ACTIVITY=
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|GENE= ARF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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}}
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'''Saccharomyces cerevisiae ADP-ribosylation Factor 2 (ScArf2) complexed with GDP-3'P at 1.6A resolution'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1MR3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=G3D:'>G3D</scene>, <scene name='pdbligand=EDO:'>EDO</scene>, <scene name='pdbligand=GOL:'>GOL</scene>, <scene name='pdbligand=EOH:'>EOH</scene> and <scene name='pdbligand=PDO:'>PDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MR3 OCA].
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1MR3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MR3 OCA].
==Reference==
==Reference==
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Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases., Amor JC, Horton JR, Zhu X, Wang Y, Sullards C, Ringe D, Cheng X, Kahn RA, J Biol Chem. 2001 Nov 9;276(45):42477-84. Epub 2001 Sep 4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11535602 11535602]
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Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases., Amor JC, Horton JR, Zhu X, Wang Y, Sullards C, Ringe D, Cheng X, Kahn RA, J Biol Chem. 2001 Nov 9;276(45):42477-84. Epub 2001 Sep 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11535602 11535602]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: small gtpase]]
[[Category: small gtpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:58:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:47:06 2008''

Revision as of 10:47, 20 March 2008

Image:1mr3.gif


PDB ID 1mr3

Drag the structure with the mouse to rotate
, resolution 1.60Å
Ligands: , , , , and
Gene: ARF2 (Saccharomyces cerevisiae)
Coordinates: save as pdb, mmCIF, xml



Saccharomyces cerevisiae ADP-ribosylation Factor 2 (ScArf2) complexed with GDP-3'P at 1.6A resolution


Overview

Structures were determined by x-ray crystallography for two members of the ADP-ribosylation factor (ARF) family of regulatory GTPases, yeast ARF1 and ARL1, and were compared with previously determined structures of human ARF1 and ARF6. These analyses revealed an overall conserved fold but differences in primary sequence and length, particularly in an N-terminal loop, lead to differences in nucleotide and divalent metal binding. Packing of hydrophobic residues is central to the interplay between the N-terminal alpha-helix, switch I, and the interswitch region, which along with differences in surface electrostatics provide explanations for the different biophysical and biochemical properties of ARF and ARF-like proteins.

About this Structure

1MR3 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases., Amor JC, Horton JR, Zhu X, Wang Y, Sullards C, Ringe D, Cheng X, Kahn RA, J Biol Chem. 2001 Nov 9;276(45):42477-84. Epub 2001 Sep 4. PMID:11535602

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