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3hag

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[[Image:3hag.png|left|200px]]
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==Crystal structure of the Hepatitis E Virus-like Particle==
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<StructureSection load='3hag' size='340' side='right' caption='[[3hag]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3hag]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_e_virus_type_4 Hepatitis e virus type 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HAG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HAG FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hag OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hag RCSB], [http://www.ebi.ac.uk/pdbsum/3hag PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hepatitis E virus (HEV), a small, non-enveloped RNA virus in the family Hepeviridae, is associated with endemic and epidemic acute viral hepatitis in developing countries. Our 3.5-A structure of a HEV-like particle (VLP) shows that each capsid protein contains 3 linear domains that form distinct structural elements: S, the continuous capsid; P1, 3-fold protrusions; and P2, 2-fold spikes. The S domain adopts a jelly-roll fold commonly observed in small RNA viruses. The P1 and P2 domains both adopt beta-barrel folds. Each domain possesses a potential polysaccharide-binding site that may function in cell-receptor binding. Sugar binding to P1 at the capsid protein interface may lead to capsid disassembly and cell entry. Structural modeling indicates that native T = 3 capsid contains flat dimers, with less curvature than those of T = 1 VLP. Our findings significantly advance the understanding of HEV molecular biology and have application to the development of vaccines and antiviral medications.
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{{STRUCTURE_3hag| PDB=3hag | SCENE= }}
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Structure of the hepatitis E virus-like particle suggests mechanisms for virus assembly and receptor binding.,Guu TS, Liu Z, Ye Q, Mata DA, Li K, Yin C, Zhang J, Tao YJ Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12992-7. Epub 2009 Jul 21. PMID:19622744<ref>PMID:19622744</ref>
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===Crystal structure of the Hepatitis E Virus-like Particle===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19622744}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3hag]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_e_virus_type_4 Hepatitis e virus type 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HAG OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019622744</ref><references group="xtra"/>
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[[Category: Hepatitis e virus type 4]]
[[Category: Hepatitis e virus type 4]]
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[[Category: Guu, T S.Y.]]
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[[Category: Guu, T S.Y]]
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[[Category: Li, K.]]
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[[Category: Li, K]]
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[[Category: Liu, Z.]]
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[[Category: Liu, Z]]
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[[Category: Mata, D A.]]
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[[Category: Mata, D A]]
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[[Category: Tao, Y J.]]
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[[Category: Tao, Y J]]
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[[Category: Ye, Q.]]
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[[Category: Ye, Q]]
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[[Category: Yin, C.]]
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[[Category: Yin, C]]
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[[Category: Zhang, J.]]
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[[Category: Zhang, J]]
[[Category: Beta barrel]]
[[Category: Beta barrel]]
[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
[[Category: Jelly-roll beta sheet]]
[[Category: Jelly-roll beta sheet]]
[[Category: Virus]]
[[Category: Virus]]

Revision as of 09:31, 8 December 2014

Crystal structure of the Hepatitis E Virus-like Particle

3hag, resolution 3.50Å

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