2jcd
From Proteopedia
(New page: 200px<br /> <applet load="2jcd" size="450" color="white" frame="true" align="right" spinBox="true" caption="2jcd, resolution 2.11Å" /> '''STRUCTURE OF THE N-...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2JCD is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptomyces_thioluteus Streptomyces thioluteus]] with MN and EDO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JCD OCA]]. | + | 2JCD is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptomyces_thioluteus Streptomyces thioluteus]] with MN and EDO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JCD OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 17:50:25 2007'' |
Revision as of 15:45, 30 October 2007
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STRUCTURE OF THE N-OXYGENASE AURF FROM STREPTOMYCES THIOLUTEUS
Overview
Nitro groups are found in a number of bioactive compounds. Most of them, arise by a stepwise mono-oxygenation of amino groups. One of the involved, enzymes is AurF participating in the biosynthesis of aureothin. Its, structure was established at 2.1 A resolution showing a homodimer with a, binuclear manganese cluster. The enzyme preparation, which yielded the, analyzed crystals, showed activity using in vitro and in vivo assays., Chain fold and cluster are homologous with ribonucleotide reductase, subunit R2 and related enzymes. The two manganese ions and an iron content, of about 15% were established by anomalous X-ray diffraction. A comparison, of the cluster with more common di-iron clusters suggested an additional, histidine in the coordination sphere to cause the preference for ... [(full description)]
About this Structure
2JCD is a [Single protein] structure of sequence from [Streptomyces thioluteus] with MN and EDO as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure and Action of the N-oxygenase AurF from Streptomyces thioluteus., Zocher G, Winkler R, Hertweck C, Schulz GE, J Mol Biol. 2007 Jun 9;. PMID:17765264
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