1msa
From Proteopedia
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| - | [[Image:1msa.gif|left|200px]] | + | [[Image:1msa.gif|left|200px]] |
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| - | '''MANNOSE-SPECIFIC AGGLUTININ (LECTIN) FROM SNOWDROP (GALANTHUS NIVALIS) BULBS COMPLEXED WITH METHYL-ALPHA-D-MANNOSIDE''' | + | {{Structure |
| + | |PDB= 1msa |SIZE=350|CAPTION= <scene name='initialview01'>1msa</scene>, resolution 2.29Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''MANNOSE-SPECIFIC AGGLUTININ (LECTIN) FROM SNOWDROP (GALANTHUS NIVALIS) BULBS COMPLEXED WITH METHYL-ALPHA-D-MANNOSIDE''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1MSA is a [ | + | 1MSA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Galanthus_nivalis Galanthus nivalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSA OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of mannose-specific snowdrop (Galanthus nivalis) lectin is representative of a new plant lectin family., Hester G, Kaku H, Goldstein IJ, Wright CS, Nat Struct Biol. 1995 Jun;2(6):472-9. PMID:[http:// | + | Structure of mannose-specific snowdrop (Galanthus nivalis) lectin is representative of a new plant lectin family., Hester G, Kaku H, Goldstein IJ, Wright CS, Nat Struct Biol. 1995 Jun;2(6):472-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7664110 7664110] |
[[Category: Galanthus nivalis]] | [[Category: Galanthus nivalis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: methyl-alpha-d-mannoside]] | [[Category: methyl-alpha-d-mannoside]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:47:46 2008'' |
Revision as of 10:47, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
MANNOSE-SPECIFIC AGGLUTININ (LECTIN) FROM SNOWDROP (GALANTHUS NIVALIS) BULBS COMPLEXED WITH METHYL-ALPHA-D-MANNOSIDE
Overview
Tetrameric Galanthus nivalis agglutinin (50,000 M(r)) belongs to a super-family of alpha-D-mannose-specific plant bulb lectins known to be potent inhibitors of retroviruses. The 2.3 A crystal structure of this lectin complexed with methyl alpha-D-mannose reveals a novel three-fold symmetric beta-sheet polypeptide fold. Three antiparallel four-stranded beta-sheets, each with a conserved mannose-binding site, are arranged as a 12-stranded beta-barrel. The tetramer displays 222 symmetry. Pairs of monomers form stable dimers through C-terminal strand exchange. The so formed hybrid beta-sheets are the sites for high affinity mannose binding in the dimer interface. Occupancy observed at corresponding sites in other beta-sheets suggests a potential for twelve sites per tetramer.
About this Structure
1MSA is a Single protein structure of sequence from Galanthus nivalis. Full crystallographic information is available from OCA.
Reference
Structure of mannose-specific snowdrop (Galanthus nivalis) lectin is representative of a new plant lectin family., Hester G, Kaku H, Goldstein IJ, Wright CS, Nat Struct Biol. 1995 Jun;2(6):472-9. PMID:7664110
Page seeded by OCA on Thu Mar 20 12:47:46 2008
