1msp
From Proteopedia
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| - | [[Image:1msp.gif|left|200px]] | + | [[Image:1msp.gif|left|200px]] |
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| - | '''MAJOR SPERM PROTEIN, ALPHA ISOFORM (RECOMBINANT), PH 4.6''' | + | {{Structure |
| + | |PDB= 1msp |SIZE=350|CAPTION= <scene name='initialview01'>1msp</scene>, resolution 2.5Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= ALPHA MSP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6253 Ascaris suum]) | ||
| + | }} | ||
| + | |||
| + | '''MAJOR SPERM PROTEIN, ALPHA ISOFORM (RECOMBINANT), PH 4.6''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1MSP is a [ | + | 1MSP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ascaris_suum Ascaris suum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSP OCA]. |
==Reference== | ==Reference== | ||
| - | 2.5 A resolution crystal structure of the motile major sperm protein (MSP) of Ascaris suum., Bullock TL, Roberts TM, Stewart M, J Mol Biol. 1996 Oct 25;263(2):284-96. PMID:[http:// | + | 2.5 A resolution crystal structure of the motile major sperm protein (MSP) of Ascaris suum., Bullock TL, Roberts TM, Stewart M, J Mol Biol. 1996 Oct 25;263(2):284-96. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8913307 8913307] |
[[Category: Ascaris suum]] | [[Category: Ascaris suum]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: sperm]] | [[Category: sperm]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:47:44 2008'' |
Revision as of 10:47, 20 March 2008
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| , resolution 2.5Å | |||||||
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| Gene: | ALPHA MSP (Ascaris suum) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
MAJOR SPERM PROTEIN, ALPHA ISOFORM (RECOMBINANT), PH 4.6
Overview
We have determined the structure of the Ascaris major sperm protein (MSP) to 2.5 A resolution using X-ray crystallography. The MSP polypeptide chain has an immunoglobulin-like fold based on a seven-stranded beta sandwich. In two strands, cis-proline residues impart distinctive kinks, and overall the structure most closely resembles that of the N-terminal domain of the bacterial chaperonin, PapD. In the C2 crystal form which we have solved here, two MSP chains are tightly associated in the asymmetric unit and are related by a non-crystallographic 2-fold rotation axis. This arrangement almost certainly represents the MSP dimer that is present in solution. Additionally, the arrangement of two MSP dimers at one of the crystallographic 2-fold axes in the 215 A unit cell suggests a possible mode for the assembly of MSP into the filaments which promote cell movement. This dimer-dimer association is based on a beta sheet extension mechanism between adjoining MSP monomers which resembles the interaction between PapD and its protein substrate.
About this Structure
1MSP is a Single protein structure of sequence from Ascaris suum. Full crystallographic information is available from OCA.
Reference
2.5 A resolution crystal structure of the motile major sperm protein (MSP) of Ascaris suum., Bullock TL, Roberts TM, Stewart M, J Mol Biol. 1996 Oct 25;263(2):284-96. PMID:8913307
Page seeded by OCA on Thu Mar 20 12:47:44 2008
