1mtl

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[[Image:1mtl.jpg|left|200px]]<br /><applet load="1mtl" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1mtl.jpg|left|200px]]
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caption="1mtl, resolution 2.80&Aring;" />
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'''Non-productive MUG-DNA complex'''<br />
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{{Structure
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|PDB= 1mtl |SIZE=350|CAPTION= <scene name='initialview01'>1mtl</scene>, resolution 2.80&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= MUG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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}}
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'''Non-productive MUG-DNA complex'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1MTL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MTL OCA].
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1MTL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MTL OCA].
==Reference==
==Reference==
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Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct., Barrett TE, Savva R, Barlow T, Brown T, Jiricny J, Pearl LH, Nat Struct Biol. 1998 Aug;5(8):697-701. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9699633 9699633]
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Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct., Barrett TE, Savva R, Barlow T, Brown T, Jiricny J, Pearl LH, Nat Struct Biol. 1998 Aug;5(8):697-701. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9699633 9699633]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: non-productive]]
[[Category: non-productive]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:58:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:47:58 2008''

Revision as of 10:48, 20 March 2008

Image:1mtl.jpg


PDB ID 1mtl

Drag the structure with the mouse to rotate
, resolution 2.80Å
Gene: MUG (Escherichia coli)
Coordinates: save as pdb, mmCIF, xml



Non-productive MUG-DNA complex


Overview

Base-excision of a self-complementary oligonucleotide with central G:T mismatches by the G:T/U-specific mismatch DNA glycosylase (MUG), generates an unusual DNA structure which is remarkably similar in conformation to an interstrand DNA adduct of the anti-tumor drug cis-diamminedichloroplatinum. The abasic sugars generated by excision of the mismatched thymines are extruded from the double-helix, and the 'widowed' deoxyguanosines rotate so that their N7 and O6 groups protrude into the minor groove of the duplex and restack in an interleaved intercalative geometry, generating a kink in the helix axis.

About this Structure

1MTL is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct., Barrett TE, Savva R, Barlow T, Brown T, Jiricny J, Pearl LH, Nat Struct Biol. 1998 Aug;5(8):697-701. PMID:9699633

Page seeded by OCA on Thu Mar 20 12:47:58 2008

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