3ino
From Proteopedia
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| - | [[ | + | ==1.95A Resolution Structure of Protective Antigen Domain 4== |
| + | <StructureSection load='3ino' size='340' side='right' caption='[[3ino]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3ino]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3INO FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pagA, pag, pXO1-110, BXA0164, GBAA_pXO1_0164 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ino FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ino OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ino RCSB], [http://www.ebi.ac.uk/pdbsum/3ino PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Domain 4 of the anthrax protective antigen (PA) plays a key role in cellular receptor recognition as well as in pH-dependent pore formation. We present here the 1.95 A crystal structure of domain 4, which adopts a fold that is identical to that observed in the full-length protein. We have also investigated the structural properties of the isolated domain 4 as a function of pH, as well as the pH-dependence on binding to the von Willebrand factor A domain of capillary morphogenesis protein 2 (CMG2). Our results provide evidence that the isolated domain 4 maintains structure and interactions with CMG2 at pH 5, a pH that is known to cause release of the receptor on conversion of the heptameric prepore (PA(63))(7) to a membrane-spanning pore. Our results suggest that receptor release is not driven solely by a pH-induced unfolding of domain 4. | ||
| - | + | Domain 4 of the anthrax protective antigen maintains structure and binding to the host receptor CMG2 at low pH.,Williams AS, Lovell S, Anbanandam A, El-Chami R, Bann JG Protein Sci. 2009 Nov;18(11):2277-86. PMID:19722284<ref>PMID:19722284</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Anthrax protective antigen|Anthrax protective antigen]] | *[[Anthrax protective antigen|Anthrax protective antigen]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Bacillus anthracis]] | [[Category: Bacillus anthracis]] | ||
| - | [[Category: Anbanandam, A | + | [[Category: Anbanandam, A]] |
| - | [[Category: Bann, J G | + | [[Category: Bann, J G]] |
| - | [[Category: El-Chami, R | + | [[Category: El-Chami, R]] |
| - | [[Category: Lovell, S | + | [[Category: Lovell, S]] |
| - | [[Category: Williams, A S | + | [[Category: Williams, A S]] |
[[Category: Anthrax]] | [[Category: Anthrax]] | ||
[[Category: Cleavage on pair of basic residue]] | [[Category: Cleavage on pair of basic residue]] | ||
Revision as of 09:35, 8 December 2014
1.95A Resolution Structure of Protective Antigen Domain 4
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