2xya
From Proteopedia
(Difference between revisions)
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| - | [[ | + | ==NON-COVALENT INHIBTORS OF RHINOVIRUS 3C PROTEASE.== |
| + | <StructureSection load='2xya' size='340' side='right' caption='[[2xya]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2xya]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_rhinovirus_sp. Human rhinovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XYA FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7L4:2-PHENYLQUINOLIN-4-OL'>7L4</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a3r|1a3r]], [[1cqq|1cqq]], [[2hrv|2hrv]], [[1v9u|1v9u]], [[1fpn|1fpn]]</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Picornain_3C Picornain 3C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.28 3.4.22.28] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xya OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xya RCSB], [http://www.ebi.ac.uk/pdbsum/2xya PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The first known non-covalent inhibitors of rhinovirus 3C protease (3CP) have been identified through fragment based screening and hit identification activities. | ||
| - | + | Non-covalent inhibitors of rhinovirus 3C protease.,Baxter A, Chambers M, Edfeldt F, Edman K, Freeman A, Johansson C, King S, Morley A, Petersen J, Rawlins P, Spadola L, Thong B, Van de Poel H, Williams N Bioorg Med Chem Lett. 2011 Jan 15;21(2):777-80. Epub 2010 Nov 26. PMID:21183345<ref>PMID:21183345</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Human rhinovirus sp]] | |
| - | == | + | |
| - | < | + | |
| - | [[Category: Human rhinovirus sp | + | |
[[Category: Picornain 3C]] | [[Category: Picornain 3C]] | ||
| - | [[Category: Edfeldt, F | + | [[Category: Edfeldt, F]] |
| - | [[Category: Edman, K | + | [[Category: Edman, K]] |
| - | [[Category: Johansson, C | + | [[Category: Johansson, C]] |
| - | [[Category: Petersen, J | + | [[Category: Petersen, J]] |
[[Category: Cysteine protease]] | [[Category: Cysteine protease]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 09:38, 8 December 2014
NON-COVALENT INHIBTORS OF RHINOVIRUS 3C PROTEASE.
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