3hah

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[[Image:3hah.png|left|200px]]
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==Crystal structure of human PACSIN1 F-BAR domain (C2 lattice)==
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<StructureSection load='3hah' size='340' side='right' caption='[[3hah]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3hah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HAH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3hai|3hai]], [[3haj|3haj]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIAA1379, PACSIN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hah RCSB], [http://www.ebi.ac.uk/pdbsum/3hah PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/3hah_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Peripheral membrane proteins of the Bin/amphiphysin/Rvs (BAR) and Fer-CIP4 homology-BAR (F-BAR) family participate in cellular membrane trafficking and have been shown to generate membrane tubules. The degree of membrane bending appears to be encoded in the structure and immanent curvature of the particular protein domains, with BAR and F-BAR domains inducing high- and low-curvature tubules, respectively. In addition, oligomerization and the formation of ordered arrays influences tubule stabilization. Here, the F-BAR domain-containing protein Pacsin was found to possess a unique activity, creating small tubules and tubule constrictions, in addition to the wide tubules characteristic for this subfamily. Based on crystal structures of the F-BAR domain of Pacsin and mutagenesis studies, vesiculation could be linked to the presence of unique structural features distinguishing it from other F-BAR proteins. Tubulation was suppressed in the context of the full-length protein, suggesting that Pacsin is autoinhibited in solution. The regulated deformation of membranes and promotion of tubule constrictions by Pacsin suggests a more versatile function of these proteins in vesiculation and endocytosis beyond their role as scaffold proteins.
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{{STRUCTURE_3hah| PDB=3hah | SCENE= }}
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Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin.,Wang Q, Navarro MV, Peng G, Molinelli E, Lin Goh S, Judson BL, Rajashankar KR, Sondermann H Proc Natl Acad Sci U S A. 2009 Jun 24. PMID:19549836<ref>PMID:19549836</ref>
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===Crystal structure of human PACSIN1 F-BAR domain (C2 lattice)===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19549836}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3hah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HAH OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019549836</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Navarro, M V.A S.]]
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[[Category: Navarro, M V.A S]]
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[[Category: Peng, G.]]
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[[Category: Peng, G]]
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[[Category: Rajashankar, K R.]]
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[[Category: Rajashankar, K R]]
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[[Category: Sondermann, H.]]
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[[Category: Sondermann, H]]
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[[Category: Wang, Q.]]
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[[Category: Wang, Q]]
[[Category: Endocytosis]]
[[Category: Endocytosis]]
[[Category: F-bar]]
[[Category: F-bar]]

Revision as of 09:41, 8 December 2014

Crystal structure of human PACSIN1 F-BAR domain (C2 lattice)

3hah, resolution 2.77Å

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