2v9y
From Proteopedia
(New page: 200px<br /> <applet load="2v9y" size="450" color="white" frame="true" align="right" spinBox="true" caption="2v9y, resolution 2.10Å" /> '''HUMAN AMINOIMIDAZOL...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2V9Y is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.1 6.3.3.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V9Y OCA]]. | + | 2V9Y is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Phosphoribosylformylglycinamidine_cyclo-ligase Phosphoribosylformylglycinamidine cyclo-ligase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.1 6.3.3.1]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V9Y OCA]]. |
==Reference== | ==Reference== | ||
X-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 A resolution., Li C, Kappock TJ, Stubbe J, Weaver TM, Ealick SE, Structure. 1999 Sep 15;7(9):1155-66. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10508786 10508786] | X-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 A resolution., Li C, Kappock TJ, Stubbe J, Weaver TM, Ealick SE, Structure. 1999 Sep 15;7(9):1155-66. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10508786 10508786] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Phosphoribosylformylglycinamidine cyclo-ligase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Arrowsmith, C.H.]] | [[Category: Arrowsmith, C.H.]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 17:51:07 2007'' |
Revision as of 15:46, 30 October 2007
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HUMAN AMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE
Overview
BACKGROUND: The purine biosynthetic pathway in procaryotes enlists eleven, enzymes, six of which use ATP. Enzymes 5 and 6 of this pathway, formylglycinamide ribonucleotide (FGAR) amidotransferase (PurL) and, aminoimidazole ribonucleotide (AIR) synthetase (PurM) utilize ATP to, activate the oxygen of an amide within their substrate toward nucleophilic, attack by a nitrogen. AIR synthetase uses the product of PurL, formylglycinamidine ribonucleotide (FGAM) and ATP to make AIR, ADP and, P(i). RESULTS: The structure of a hexahistidine-tagged PurM has been, solved by multiwavelength anomalous diffraction phasing techniques using, protein containing 28 selenomethionines per asymmetric unit. The final, model of PurM consists of two crystallographically independent dimers and, four sulfates. The ... [(full description)]
About this Structure
2V9Y is a [Single protein] structure of sequence from [Homo sapiens] with SO4 as [ligand]. Active as [Phosphoribosylformylglycinamidine cyclo-ligase], with EC number [6.3.3.1]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
X-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 A resolution., Li C, Kappock TJ, Stubbe J, Weaver TM, Ealick SE, Structure. 1999 Sep 15;7(9):1155-66. PMID:10508786
Page seeded by OCA on Tue Oct 30 17:51:07 2007
Categories: Homo sapiens | Phosphoribosylformylglycinamidine cyclo-ligase | Single protein | Arrowsmith, C.H. | Berg, S.Van.Den. | Berglund, H. | Busam, R. | Collins, R. | Consortium, Structural.Genomics. | Dahlgren, L.G. | Edwards, A. | Flodin, S. | Flores, A. | Graslund, S. | Hallberg, B.M. | Hammarstrom, M. | Herman, M.D. | Holmberg-Schiavone, L. | Johansson, I. | Kallas, A. | Karlberg, T. | Kotenyova, T. | Lehtio, L. | Moche, M. | Nordlund, P. | Nyman, T. | Persson, C. | Sagemark, J. | Stenmark, P. | Sundstrom, M. | Thorsell, A.G. | Tresaugues, L. | Weigelt, J. | Welin, M. | SO4 | Airs | Alternative splicing | Aminoimidazole ribonucleotide synthetase | Atp-binding | Gart | Ligase | Multifunctional enzyme | Nucleotide-binding | Phosphorylation | Polymorphism | Purine biosynthesis | Purine metabolism | Sgc | Structural genomics | Structural genomics consortium | Transferase
