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3mts

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[[Image:3mts.png|left|200px]]
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==Chromo Domain of Human Histone-Lysine N-Methyltransferase SUV39H1==
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<StructureSection load='3mts' size='340' side='right' caption='[[3mts]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3mts]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MTS FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KMT1A, SUV39H, SUV39H1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mts FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mts OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mts RCSB], [http://www.ebi.ac.uk/pdbsum/3mts PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mt/3mts_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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SUV39H1, the first identified histone lysine methyltransferase in human, is involved in chromatin modification and gene regulation. SUV39H1 contains a chromodomain in its N-terminus, which potentially plays a role in methyl-lysine recognition and SUV39H1 targeting. In this study, the structure of the chromodomain of human SUV39H1 was determined by X-ray crystallography. The SUV39H1 chromodomain displays a generally conserved structure fold compared with other solved chromodomains. However, different from other chromodomains, the SUV39H1 chromodomain possesses a much longer helix at its C-terminus. Furthermore, the SUV39H1 chromodomain was shown to recognize histone H3K9me2/3 specifically.
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{{STRUCTURE_3mts| PDB=3mts | SCENE= }}
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Crystal Structure of the Human SUV39H1 Chromodomain and Its Recognition of Histone H3K9me2/3.,Wang T, Xu C, Liu Y, Fan K, Li Z, Sun X, Ouyang H, Zhang X, Zhang J, Li Y, Mackenzie F, Min J, Tu X PLoS One. 2012;7(12):e52977. doi: 10.1371/journal.pone.0052977. Epub 2012 Dec 28. PMID:23285239<ref>PMID:23285239</ref>
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===Chromo Domain of Human Histone-Lysine N-Methyltransferase SUV39H1===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_23285239}}
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==About this Structure==
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[[3mts]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTS OCA].
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==See Also==
==See Also==
*[[Histone methyltransferase|Histone methyltransferase]]
*[[Histone methyltransferase|Histone methyltransferase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Histone-lysine N-methyltransferase]]
[[Category: Histone-lysine N-methyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev, A]]
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[[Category: Bountra, C.]]
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[[Category: Bountra, C]]
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[[Category: Crombet, L.]]
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[[Category: Crombet, L]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards, A M]]
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[[Category: Lam, R.]]
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[[Category: Lam, R]]
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[[Category: Li, Z.]]
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[[Category: Li, Z]]
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[[Category: Min, J.]]
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[[Category: Min, J]]
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[[Category: Ouyang, H.]]
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[[Category: Ouyang, H]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Walker, J R.]]
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[[Category: Walker, J R]]
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[[Category: Wang, J.]]
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[[Category: Wang, J]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt, J]]
[[Category: Chromatin]]
[[Category: Chromatin]]
[[Category: Chromo domain]]
[[Category: Chromo domain]]
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[[Category: Set domain]]
[[Category: Set domain]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
 
[[Category: Suv39h1]]
[[Category: Suv39h1]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]

Revision as of 09:17, 9 December 2014

Chromo Domain of Human Histone-Lysine N-Methyltransferase SUV39H1

3mts, resolution 2.20Å

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