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1n11

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[[Image:1n11.gif|left|200px]]<br /><applet load="1n11" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1n11.gif|left|200px]]
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caption="1n11, resolution 2.70&Aring;" />
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'''D34 REGION OF HUMAN ANKYRIN-R AND LINKER'''<br />
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{{Structure
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|PDB= 1n11 |SIZE=350|CAPTION= <scene name='initialview01'>1n11</scene>, resolution 2.70&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene> and <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene>
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|ACTIVITY=
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|GENE= ank-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''D34 REGION OF HUMAN ANKYRIN-R AND LINKER'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1N11 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=BR:'>BR</scene> and <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N11 OCA].
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1N11 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N11 OCA].
==Reference==
==Reference==
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Crystal structure of a 12 ANK repeat stack from human ankyrinR., Michaely P, Tomchick DR, Machius M, Anderson RG, EMBO J. 2002 Dec 2;21(23):6387-96. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12456646 12456646]
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Crystal structure of a 12 ANK repeat stack from human ankyrinR., Michaely P, Tomchick DR, Machius M, Anderson RG, EMBO J. 2002 Dec 2;21(23):6387-96. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12456646 12456646]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: clathrin]]
[[Category: clathrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:01:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:50:42 2008''

Revision as of 10:50, 20 March 2008

Image:1n11.gif


PDB ID 1n11

Drag the structure with the mouse to rotate
, resolution 2.70Å
Ligands: and
Gene: ank-1 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



D34 REGION OF HUMAN ANKYRIN-R AND LINKER


Contents

Overview

Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. The N-terminal, 'membrane-binding' domain of ankyrins contains 24 ANK repeats and mediates most binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. Here we report the crystal structure of a human ankyrinR construct containing ANK repeats 13-24 and a portion of the spectrin-binding domain. The ANK repeats are observed to form a contiguous spiral stack with which the spectrin-binding domain fragment associates as an extended strand. The structural information has been used to construct models of all 24 repeats of the membrane-binding domain as well as the interactions of the repeats with the Cl/HCO(3) anion exchanger and clathrin. These models, together with available binding studies, suggest that ion transporters such as the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.

Disease

Known diseases associated with this structure: Chondrocalcinosis 2 OMIM:[605145], Craniometaphyseal dysplasia OMIM:[605145]

About this Structure

1N11 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a 12 ANK repeat stack from human ankyrinR., Michaely P, Tomchick DR, Machius M, Anderson RG, EMBO J. 2002 Dec 2;21(23):6387-96. PMID:12456646

Page seeded by OCA on Thu Mar 20 12:50:42 2008

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