3ln8
From Proteopedia
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| - | [[ | + | ==The X-ray structure of Zf-RNase-1 from a new crystal form at pH 7.3== |
| + | <StructureSection load='3ln8' size='340' side='right' caption='[[3ln8]], [[Resolution|resolution]] 1.61Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3ln8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LN8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vq8|2vq8]], [[2vq9|2vq9]], [[3ljd|3ljd]], [[3lje|3lje]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ln8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ln8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ln8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ln8 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Only recently extracellular RNases of the RNase A superfamily, with the characteristic CKxxNTF sequence signature, have been identified in fish. This has led to the recognition that these RNases are present in the whole vertebrate sub-phylum. In fact, they comprise the only enzyme family unique to vertebrates. Four RNases from zebrafish (Danio rerio) have been previously reported, with a very low RNase activity, some endowed, like human angiogenin, with powerful angiogenic and bactericidal activities. Here we report the three-dimensional structure, the thermodynamic behaviour, and the biological properties of a novel zebrafish RNase, ZF-RNase-5. The investigation of its structural and functional properties, extended to all other sub-family members, provides an inclusive description of the whole zebrafish RNase sub-family. | ||
| - | + | A new RNase sheds light on the RNase/angiogenin subfamily from zebrafish.,Pizzo E, Merlino A, Turano M, Russo Krauss I, Coscia F, Zanfardino A, Varcamonti M, Furia A, Giancola C, Mazzarella L, Sica F, D'Alessio G Biochem J. 2010 Nov 4. PMID:21050179<ref>PMID:21050179</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Ribonuclease|Ribonuclease]] | *[[Ribonuclease|Ribonuclease]] | ||
| - | + | *[[User:Jaime.Prilusky/Test/tree|User:Jaime.Prilusky/Test/tree]] | |
| - | == | + | == References == |
| - | < | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Danio rerio]] | [[Category: Danio rerio]] | ||
| - | [[Category: Krauss, I Russo | + | [[Category: Krauss, I Russo]] |
| - | [[Category: Mazzarella, L | + | [[Category: Mazzarella, L]] |
| - | [[Category: Merlino, A | + | [[Category: Merlino, A]] |
| - | [[Category: Sica, F | + | [[Category: Sica, F]] |
[[Category: Angiogenin]] | [[Category: Angiogenin]] | ||
[[Category: Fish rnase]] | [[Category: Fish rnase]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 09:44, 9 December 2014
The X-ray structure of Zf-RNase-1 from a new crystal form at pH 7.3
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