3le6

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[[Image:3le6.png|left|200px]]
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==The structure of cyclin dependent kinase 2 (CKD2) with a pyrazolobenzodiazepine inhibitor==
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<StructureSection load='3le6' size='340' side='right' caption='[[3le6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3le6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LE6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LE6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2BZ:5-(2-CHLOROPHENYL)-3-METHYL-7-NITROPYRAZOLO[3,4-B][1,4]BENZODIAZEPINE'>2BZ</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3le6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3le6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3le6 RCSB], [http://www.ebi.ac.uk/pdbsum/3le6 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A novel series of pyrazolobenzodiazepines 3 has been identified as potent inhibitors of cyclin-dependent kinase 2 (CDK2). Their synthesis and structure-activity relationships (SAR) are described. Representative compounds from this class reversibly inhibit CDK2 activity in vitro, and block cell cycle progression in human tumor cell lines. Further exploration has revealed that this class of compounds inhibits several kinases that play critical roles in cancer cell growth and division as well as tumor angiogenesis. Together, these properties suggest a compelling basis for their use as antitumor agents.
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{{STRUCTURE_3le6| PDB=3le6 | SCENE= }}
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Pyrazolobenzodiazepines: part I. Synthesis and SAR of a potent class of kinase inhibitors.,Liu JJ, Daniewski I, Ding Q, Higgins B, Ju G, Kolinsky K, Konzelmann F, Lukacs C, Pizzolato G, Rossman P, Swain A, Thakkar K, Wei CC, Miklowski D, Yang H, Yin X, Wovkulich PM Bioorg Med Chem Lett. 2010 Oct 15;20(20):5984-7. Epub 2010 Aug 21. PMID:20832307<ref>PMID:20832307</ref>
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===The structure of cyclin dependent kinase 2 (CKD2) with a pyrazolobenzodiazepine inhibitor===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_20832307}}
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==About this Structure==
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[[3le6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LE6 OCA].
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==See Also==
==See Also==
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*[[Cell Division Protein Kinase 2|Cell Division Protein Kinase 2]]
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*[[Cell division protein kinase 2|Cell division protein kinase 2]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020832307</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Cyclin-dependent kinase]]
[[Category: Cyclin-dependent kinase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Crowther, R L.]]
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[[Category: Crowther, R L]]
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[[Category: Kammlott, R U.]]
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[[Category: Kammlott, R U]]
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[[Category: Liu, J J.]]
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[[Category: Liu, J J]]
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[[Category: Lukacs, C M.]]
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[[Category: Lukacs, C M]]
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[[Category: Swain, A.]]
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[[Category: Swain, A]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]

Revision as of 09:59, 9 December 2014

The structure of cyclin dependent kinase 2 (CKD2) with a pyrazolobenzodiazepine inhibitor

3le6, resolution 2.00Å

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