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1n4y
From Proteopedia
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| - | [[Image:1n4y.gif|left|200px]] | + | [[Image:1n4y.gif|left|200px]] |
| - | + | ||
| - | '''REFINED STRUCTURE OF KISTRIN''' | + | {{Structure |
| + | |PDB= 1n4y |SIZE=350|CAPTION= <scene name='initialview01'>1n4y</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= RHOD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8717 Calloselasma rhodostoma]) | ||
| + | }} | ||
| + | |||
| + | '''REFINED STRUCTURE OF KISTRIN''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1N4Y is a [ | + | 1N4Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure supersedes the now removed PDB entry 1KST. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4Y OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist., Adler M, Lazarus RA, Dennis MS, Wagner G, Science. 1991 Jul 26;253(5018):445-8. PMID:[http:// | + | Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist., Adler M, Lazarus RA, Dennis MS, Wagner G, Science. 1991 Jul 26;253(5018):445-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1862345 1862345] |
[[Category: Calloselasma rhodostoma]] | [[Category: Calloselasma rhodostoma]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: venom]] | [[Category: venom]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:52:13 2008'' |
Revision as of 10:52, 20 March 2008
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| Gene: | RHOD (Calloselasma rhodostoma) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
REFINED STRUCTURE OF KISTRIN
Overview
The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a series of tightly packed loops held together by six disulfide bonds and has almost no regular secondary structure. Kistrin has an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for binding to GP IIb-IIIa that is located at the apex of a long loop across the surface of the protein.
About this Structure
1N4Y is a Single protein structure of sequence from Calloselasma rhodostoma. This structure supersedes the now removed PDB entry 1KST. Full crystallographic information is available from OCA.
Reference
Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist., Adler M, Lazarus RA, Dennis MS, Wagner G, Science. 1991 Jul 26;253(5018):445-8. PMID:1862345
Page seeded by OCA on Thu Mar 20 12:52:13 2008
