3pov
From Proteopedia
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| - | [[ | + | ==Crystal structure of a SOX-DNA complex== |
| + | <StructureSection load='3pov' size='340' side='right' caption='[[3pov]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3pov]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8_type_m Human herpesvirus 8 type m]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3POV FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">orf37 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=435895 Human herpesvirus 8 type M])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pov OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pov RCSB], [http://www.ebi.ac.uk/pdbsum/3pov PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The early lytic phase of Kaposi's sarcoma herpesvirus infection is characterized by viral replication and the global degradation (shutoff) of host mRNA. Key to both activities is the virally encoded alkaline exonuclease KSHV SOX. While the DNase activity of KSHV SOX is required for the resolution of viral genomic DNA as a precursor to encapsidation, its exact involvement in host shutoff remains to be determined. We present the first crystal structure of a KSHV SOX-DNA complex that has illuminated the catalytic mechanism underpinning both its endo and exonuclease activities. We further illustrate that KSHV SOX, similar to its Epstein-Barr virus homologue, has an intrinsic RNase activity in vitro that although an element of host shutoff, cannot solely account for the phenomenon. | ||
| - | + | Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff.,Bagneris C, Briggs LC, Savva R, Ebrahimi B, Barrett TE Nucleic Acids Res. 2011 Jul;39(13):5744-56. Epub 2011 Mar 17. PMID:21421561<ref>PMID:21421561</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Cytochrome P450|Cytochrome P450]] | *[[Cytochrome P450|Cytochrome P450]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Human herpesvirus 8 type m]] | [[Category: Human herpesvirus 8 type m]] | ||
| - | [[Category: Bagneris, C | + | [[Category: Bagneris, C]] |
| - | [[Category: Barrett, T E | + | [[Category: Barrett, T E]] |
[[Category: Dna binding protein-dna complex]] | [[Category: Dna binding protein-dna complex]] | ||
[[Category: Nuclease]] | [[Category: Nuclease]] | ||
[[Category: Nucleus/cytoplasm]] | [[Category: Nucleus/cytoplasm]] | ||
[[Category: Type ii restriction endonuclease superfamily]] | [[Category: Type ii restriction endonuclease superfamily]] | ||
Revision as of 10:47, 9 December 2014
Crystal structure of a SOX-DNA complex
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