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3r84
From Proteopedia
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| - | [[ | + | ==Structure of the Mediator head subcomplex Med11/22== |
| + | <StructureSection load='3r84' size='340' side='right' caption='[[3r84]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3r84]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R84 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R84 FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MED11, YM9718.11C, YMR112C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), MED22, SRB6, YBR1721, YBR253W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r84 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r84 RCSB], [http://www.ebi.ac.uk/pdbsum/3r84 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Mediator is a multiprotein co-activator of RNA polymerase (Pol) II transcription. Mediator contains a conserved core that comprises the 'head' and 'middle' modules. We present here a structure-function analysis of the essential Med11/22 heterodimer, a part of the head module. Med11/22 forms a conserved four-helix bundle domain with C-terminal extensions, which bind the central head subunit Med17. A highly conserved patch on the bundle surface is required for stable transcription pre-initiation complex formation on a Pol II promoter in vitro and in vivo and may recruit the general transcription factor TFIIH. The bundle domain fold is also present in the Mediator middle module subcomplex Med7/21 and is predicted in the Mediator heterodimers Med2/3, Med4/9, Med10/14 and Med28/30. The bundle domain thus represents a common building block that has been multiplied and functionally diversified during Mediator evolution in eukaryotes. | ||
| - | + | Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization.,Seizl M, Lariviere L, Pfaffeneder T, Wenzeck L, Cramer P Nucleic Acids Res. 2011 Apr 15. PMID:21498544<ref>PMID:21498544</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Mediator|Mediator]] | *[[Mediator|Mediator]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Cramer, P | + | [[Category: Cramer, P]] |
| - | [[Category: Lariviere, L | + | [[Category: Lariviere, L]] |
| - | [[Category: Pfaffenender, T | + | [[Category: Pfaffenender, T]] |
| - | [[Category: Seizl, M | + | [[Category: Seizl, M]] |
| - | [[Category: Wenzeck, L | + | [[Category: Wenzeck, L]] |
[[Category: Four-helix bundle]] | [[Category: Four-helix bundle]] | ||
[[Category: Nucleus]] | [[Category: Nucleus]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
Revision as of 10:52, 9 December 2014
Structure of the Mediator head subcomplex Med11/22
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