3r45

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3r45.png|left|200px]]
+
==Structure of a CENP-A-Histone H4 Heterodimer in complex with chaperone HJURP==
 +
<StructureSection load='3r45' size='340' side='right' caption='[[3r45]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3r45]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R45 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R45 FirstGlance]. <br>
 +
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CENPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), HJURP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r45 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r45 RCSB], [http://www.ebi.ac.uk/pdbsum/3r45 PDBsum]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
In higher eukaryotes, the centromere is epigenetically specified by the histone H3 variant Centromere Protein-A (CENP-A). Deposition of CENP-A to the centromere requires histone chaperone HJURP (Holliday junction recognition protein). The crystal structure of an HJURP-CENP-A-histone H4 complex shows that HJURP binds a CENP-A-H4 heterodimer. The C-terminal beta-sheet domain of HJURP caps the DNA-binding region of the histone heterodimer, preventing it from spontaneous association with DNA. Our analysis also revealed a novel site in CENP-A that distinguishes it from histone H3 in its ability to bind HJURP. These findings provide key information for specific recognition of CENP-A and mechanistic insights into the process of centromeric chromatin assembly.
-
{{STRUCTURE_3r45| PDB=3r45 | SCENE= }}
+
Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP.,Hu H, Liu Y, Wang M, Fang J, Huang H, Yang N, Li Y, Wang J, Yao X, Shi Y, Li G, Xu RM Genes Dev. 2011 May 1;25(9):901-6. Epub 2011 Apr 8. PMID:21478274<ref>PMID:21478274</ref>
-
===Structure of a CENP-A-Histone H4 Heterodimer in complex with chaperone HJURP===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
{{ABSTRACT_PUBMED_21478274}}
+
-
 
+
-
==About this Structure==
+
-
[[3r45]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R45 OCA].
+
==See Also==
==See Also==
 +
*[[Centromere protein|Centromere protein]]
*[[Histone|Histone]]
*[[Histone|Histone]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:021478274</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Fang, J.]]
+
[[Category: Fang, J]]
-
[[Category: Hu, H.]]
+
[[Category: Hu, H]]
-
[[Category: Huang, H.]]
+
[[Category: Huang, H]]
-
[[Category: Li, G.]]
+
[[Category: Li, G]]
-
[[Category: Li, Y.]]
+
[[Category: Li, Y]]
-
[[Category: Liu, Y.]]
+
[[Category: Liu, Y]]
-
[[Category: Shi, Y.]]
+
[[Category: Shi, Y]]
-
[[Category: Wang, J.]]
+
[[Category: Wang, J]]
-
[[Category: Wang, M.]]
+
[[Category: Wang, M]]
-
[[Category: Xu, R M.]]
+
[[Category: Xu, R M]]
-
[[Category: Yang, N.]]
+
[[Category: Yang, N]]
-
[[Category: Yao, X.]]
+
[[Category: Yao, X]]
[[Category: Cenp-a]]
[[Category: Cenp-a]]
[[Category: Centromere]]
[[Category: Centromere]]

Revision as of 11:23, 9 December 2014

Structure of a CENP-A-Histone H4 Heterodimer in complex with chaperone HJURP

3r45, resolution 2.60Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3r45"
Personal tools