2v6e
From Proteopedia
(New page: 200px<br /> <applet load="2v6e" size="450" color="white" frame="true" align="right" spinBox="true" caption="2v6e, resolution 3.2Å" /> '''PROTELOMERASE TELK C...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2V6E is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Klebsiella_phage_phiko2 Klebsiella phage phiko2]] with VO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V6E OCA]]. | + | 2V6E is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Klebsiella_phage_phiko2 Klebsiella phage phiko2]] with VO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V6E OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: resolvase]] | [[Category: resolvase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 17:53:06 2007'' |
Revision as of 15:48, 30 October 2007
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PROTELOMERASE TELK COMPLEXED WITH SUBSTRATE DNA
Overview
The termini of linear chromosomes are protected by specialized DNA, structures known as telomeres that also facilitate the complete, replication of DNA ends. The simplest type of telomere is a covalently, closed DNA hairpin structure found in linear chromosomes of prokaryotes, and viruses. Bidirectional replication of a chromosome with hairpin, telomeres produces a catenated circular dimer that is subsequently, resolved into unit-length chromosomes by a dedicated DNA, cleavage-rejoining enzyme known as a hairpin telomere resolvase, (protelomerase). Here we report a crystal structure of the protelomerase, TelK from Klebsiella oxytoca phage varphiKO2, in complex with the, palindromic target DNA. The structure shows the TelK dimer destabilizes, base pairing interactions to promote the ... [(full description)]
About this Structure
2V6E is a [Single protein] structure of sequence from [Klebsiella phage phiko2] with VO4 as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
An Interlocked Dimer of the Protelomerase TelK Distorts DNA Structure for the Formation of Hairpin Telomeres., Aihara H, Huang WM, Ellenberger T, Mol Cell. 2007 Sep 21;27(6):901-13. PMID:17889664
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