3p91
From Proteopedia
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| - | [[ | + | ==Crystal structure of Proliferating Cellular Nuclear Antigen from Entamoeba histolytica== |
| + | <StructureSection load='3p91' size='340' side='right' caption='[[3p91]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3p91]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Entamoeba_histolytica Entamoeba histolytica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P91 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P91 FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EHI_128450 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5759 Entamoeba histolytica])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p91 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p91 RCSB], [http://www.ebi.ac.uk/pdbsum/3p91 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Proliferating cellular nuclear antigen (PCNA) is a toroidal-shaped protein that is involved in cell-cycle control, DNA replication and DNA repair. Parasitic protozoa are early-diverged eukaryotes that are responsible for neglected diseases. In this work, a PCNA from a parasitic protozoon was identified, cloned and biochemically characterized and its crystal structure was determined. Structural and biochemical studies demonstrate that PCNA from Entamoeba histolytica assembles as a homotrimer that is able to interact with and stimulate the activity of a PCNA-interacting peptide-motif protein from E. histolytica, EhDNAligI. The data indicate a conservation of the biochemical mechanisms of PCNA-mediated interactions between metazoa, yeast and parasitic protozoa. | ||
| - | + | Structure and biochemical characterization of proliferating cellular nuclear antigen from a parasitic protozoon.,Cardona-Felix CS, Lara-Gonzalez S, Brieba LG Acta Crystallogr D Biol Crystallogr. 2011 Jun;67(Pt 6):497-505. Epub 2011 May 12. PMID:21636889<ref>PMID:21636889</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Proliferating Cell Nuclear Antigen|Proliferating Cell Nuclear Antigen]] | *[[Proliferating Cell Nuclear Antigen|Proliferating Cell Nuclear Antigen]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Entamoeba histolytica]] | [[Category: Entamoeba histolytica]] | ||
| - | [[Category: Brieba, L G | + | [[Category: Brieba, L G]] |
| - | [[Category: Cardona-Felix, C S | + | [[Category: Cardona-Felix, C S]] |
| - | [[Category: Lara-Gonzalez, S | + | [[Category: Lara-Gonzalez, S]] |
[[Category: Dna binding protein]] | [[Category: Dna binding protein]] | ||
[[Category: Dna replication]] | [[Category: Dna replication]] | ||
[[Category: Processivity]] | [[Category: Processivity]] | ||
[[Category: Sliding clamp]] | [[Category: Sliding clamp]] | ||
Revision as of 11:28, 9 December 2014
Crystal structure of Proliferating Cellular Nuclear Antigen from Entamoeba histolytica
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