1na0
From Proteopedia
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| - | [[Image:1na0.jpg|left|200px]] | + | [[Image:1na0.jpg|left|200px]] |
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| - | '''Design of Stable alpha-Helical Arrays from an Idealized TPR Motif''' | + | {{Structure |
| + | |PDB= 1na0 |SIZE=350|CAPTION= <scene name='initialview01'>1na0</scene>, resolution 1.60Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=IPT:ISOPROPYL-1-BETA-D-THIOGALACTOSIDE'>IPT</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Design of Stable alpha-Helical Arrays from an Idealized TPR Motif''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1NA0 is a [ | + | 1NA0 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NA0 OCA]. |
==Reference== | ==Reference== | ||
| - | Design of stable alpha-helical arrays from an idealized TPR motif., Main ER, Xiong Y, Cocco MJ, D'Andrea L, Regan L, Structure. 2003 May;11(5):497-508. PMID:[http:// | + | Design of stable alpha-helical arrays from an idealized TPR motif., Main ER, Xiong Y, Cocco MJ, D'Andrea L, Regan L, Structure. 2003 May;11(5):497-508. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12737816 12737816] |
[[Category: ]] | [[Category: ]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: tpr]] | [[Category: tpr]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:54:05 2008'' |
Revision as of 10:54, 20 March 2008
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| , resolution 1.60Å | |||||||
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| Ligands: | , , , , and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Design of Stable alpha-Helical Arrays from an Idealized TPR Motif
Overview
The tetratricopeptide repeat (TPR) is a 34-amino acid alpha-helical motif that occurs in over 300 different proteins. In the different proteins, three to sixteen or more TPR motifs occur in tandem arrays and function to mediate protein-protein interactions. The binding specificity of each TPR protein is different, although the underlying structural motif is the same. Here we describe a statistical approach to the design of an idealized TPR motif. We present the high-resolution X-ray crystal structures (to 1.55 and 1.6 A) of designed TPR proteins and describe their solution properties and stability. A detailed analysis of these structures provides an understanding of the TPR motif, how it is repeated to give helical arrays with different superhelical twists, and how a very stable framework may be constructed for future functional designs.
About this Structure
1NA0 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Design of stable alpha-helical arrays from an idealized TPR motif., Main ER, Xiong Y, Cocco MJ, D'Andrea L, Regan L, Structure. 2003 May;11(5):497-508. PMID:12737816 [[Category: ]]
Page seeded by OCA on Thu Mar 20 12:54:05 2008
Categories: Protein complex | Andrea, L D. | Cocco, M. | Main, E. | Regan, L. | Xiong, Y. | ACT | CL | IPT | MG | NA | PB | Design | Tpr
