3q6f
From Proteopedia
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| - | [[ | + | ==Crystal structure of Fab of human mAb 2909 specific for quaternary neutralizing epitope of HIV-1 gp120== |
| + | <StructureSection load='3q6f' size='340' side='right' caption='[[3q6f]], [[Resolution|resolution]] 3.19Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3q6f]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q6F FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3q6g|3q6g]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q6f RCSB], [http://www.ebi.ac.uk/pdbsum/3q6f PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The quaternary neutralizing epitope (QNE) of HIV-1 gp120 is preferentially expressed on the trimeric envelope spikes of intact HIV virions, and QNE-specific monoclonal antibodies (mAbs) potently neutralize HIV-1. Here, we present the crystal structures of the Fabs of human mAb 2909 and macaque mAb 2.5B. Both mAbs have long beta hairpin CDR H3 regions >20 A in length that are each situated at the center of their respective antigen-binding sites. Computational analysis showed that the paratopes include the whole CDR H3, while additional CDR residues form shallow binding pockets. Structural modeling suggests a way to understand the configuration of QNEs and the antigen-antibody interaction for QNE mAbs. Our data will be useful in designing immunogens that may elicit potent neutralizing QNE Abs. | ||
| - | + | Structural Analysis of Human and Macaque mAbs 2909 and 2.5B: Implications for the Configuration of the Quaternary Neutralizing Epitope of HIV-1 gp120.,Spurrier B, Sampson JM, Totrov M, Li H, O'Neal T, Williams C, Robinson J, Gorny MK, Zolla-Pazner S, Kong XP Structure. 2011 May 11;19(5):691-9. PMID:21565703<ref>PMID:21565703</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Monoclonal Antibody|Monoclonal Antibody]] | *[[Monoclonal Antibody|Monoclonal Antibody]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Gorny, M K | + | [[Category: Gorny, M K]] |
| - | [[Category: Kong, X P | + | [[Category: Kong, X P]] |
| - | [[Category: Li, H | + | [[Category: Li, H]] |
| - | [[Category: Neal, T O | + | [[Category: Neal, T O]] |
| - | [[Category: Robinson, J | + | [[Category: Robinson, J]] |
| - | [[Category: Sampson, J | + | [[Category: Sampson, J]] |
| - | [[Category: Spurrier, B | + | [[Category: Spurrier, B]] |
| - | [[Category: Totrov, M | + | [[Category: Totrov, M]] |
| - | [[Category: William, C | + | [[Category: William, C]] |
| - | [[Category: Zolla-Pazner, S | + | [[Category: Zolla-Pazner, S]] |
[[Category: Igg]] | [[Category: Igg]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Neutralization of hiv-1 viruse]] | [[Category: Neutralization of hiv-1 viruse]] | ||
[[Category: Quaternary epitope of hiv-1 gp120]] | [[Category: Quaternary epitope of hiv-1 gp120]] | ||
Revision as of 11:36, 9 December 2014
Crystal structure of Fab of human mAb 2909 specific for quaternary neutralizing epitope of HIV-1 gp120
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