3sfe
From Proteopedia
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| - | [[ | + | ==crystal structure of porcine mitochondrial respiratory complex II bound with oxaloacetate and thiabendazole== |
| + | <StructureSection load='3sfe' size='340' side='right' caption='[[3sfe]], [[Resolution|resolution]] 2.81Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3sfe]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SFE FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=TMG:2-(1,3-THIAZOL-4-YL)-1H-BENZIMIDAZOLE'>TMG</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zoy|1zoy]], [[1zp0|1zp0]], [[3sfd|3sfd]]</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Succinate_dehydrogenase_(ubiquinone) Succinate dehydrogenase (ubiquinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.1 1.3.5.1] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sfe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sfe RCSB], [http://www.ebi.ac.uk/pdbsum/3sfe PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The mitochondrial respiratory complex II or succinate: ubiquinone oxidoreductase (SQR) is a key membrane complex in both the tricarboxylic acid cycle and aerobic respiration. Five disinfectant compounds were investigated with their potent inhibition effects on the ubiquinone reduction activity of the porcine mitochondrial SQR by enzymatic assay and crystallography. Crystal structure of the SQR bound with thiabendazole (TBZ) reveals a different inhibitor-binding feature at the ubiquinone binding site where a water molecule plays an important role. The obvious inhibitory effect of TBZ based on the biochemical data (IC(50) approximately 100 mumol/L) and the significant structure-based binding affinity calculation ( approximately 94 mumol/L) draw the suspicion of using TBZ as a good disinfectant compound for nematode infections treatment and fruit storage. | ||
| - | + | Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex II via a water molecule mediated binding feature.,Zhou Q, Zhai Y, Lou J, Liu M, Pang X, Sun F Protein Cell. 2011 Jul;2(7):531-42. Epub 2011 Aug 6. PMID:21822798<ref>PMID:21822798</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Succinate Dehydrogenase|Succinate Dehydrogenase]] | *[[Succinate Dehydrogenase|Succinate Dehydrogenase]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
| - | [[Category: Liu, M | + | [[Category: Liu, M]] |
| - | [[Category: Sun, F | + | [[Category: Sun, F]] |
| - | [[Category: Zhai, Y J | + | [[Category: Zhai, Y J]] |
| - | [[Category: Zhou, Q J | + | [[Category: Zhou, Q J]] |
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Succinate:ubiquinone oxidoreductase]] | [[Category: Succinate:ubiquinone oxidoreductase]] | ||
[[Category: Thiabendazole]] | [[Category: Thiabendazole]] | ||
Revision as of 11:41, 9 December 2014
crystal structure of porcine mitochondrial respiratory complex II bound with oxaloacetate and thiabendazole
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