2v9k

From Proteopedia

Revision as of 15:48, 30 October 2007

CRYSTAL STRUCTURE OF HUMAN PUS10, A NOVEL PSEUDOURIDINE SYNTHASE.

Overview

Pseudouridine (Psi) synthases catalyze the formation of one or more, specific Psis in structured RNAs. Five families of Psi synthases have been, characterized based on sequence homology. Pus10 has no significant, sequence homology to these defined families and therefore represents a new, family of Psi synthases. Initial characterization studies show that an, archael Pus10 catalyzes the universally conserved Psi55 in tRNA. We, present here the crystal structure of human Pus10 at 2.0 A resolution, which is the first structural description from this novel Psi synthase, family. Pus10 is a crescent-shaped molecule with two domains, the, universally conserved Psi synthase catalytic domain and a THUMP-containing, domain, which is unique to the Pus10 family. Superposition of the, catalytic ... [(full description)]

About this Structure

2V9K is a [Single protein] structure of sequence from [Homo sapiens] with CL, ZN, EPE and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Crystal Structure of Human Pus10, A Novel Pseudouridine Synthase., McCleverty CJ, Hornsby M, Spraggon G, Kreusch A, J Mol Biol. 2007 Aug 29;. PMID:17900615

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