S100 protein

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
-
===S100A===
+
*S100-A1
-
''S100-A1''
+
**[[1k2h]] – rCBP-1 – rat - NMR <br />
 +
**[[2k2f]] – rCBP-1 + Ca + ryanodine receptor peptide - NMR<br />
 +
**[[2kbm]] – rCBP-1 + F-actin capping protein peptide - NMR<br />
 +
**[[1zfs]], [[2lp2]] – hCBP-1 + Ca – human - NMR<br />
 +
**[[2l0p]], [[2lp3]] – hCBP-1 + Ca - NMR<br />
 +
**[[2lux]] - hCBP-1 (mutant) + Ca - NMR<br />
 +
**[[2lhl]], [[2lls]], [[2m3w]] – hCBP-1 (mutant) - NMR<br />
 +
**[[2llt]], [[2llu]] – hCBP-1 - NMR<br />
 +
**[[2jpt]] – bCBP-1 (mutant) – bovine - NMR <br />
-
[[1k2h]] – rCBP-1 – rat - NMR <br />
+
*S100-A2
-
[[2k2f]] – rCBP-1 + Ca + ryanodine receptor peptide - NMR<br />
+
-
[[2kbm]] – rCBP-1 + F-actin capping protein peptide - NMR<br />
+
-
[[1zfs]], [[2lp2]] – hCBP-1 + Ca – human - NMR<br />
+
-
[[2l0p]], [[2lp3]] – hCBP-1 + Ca - NMR<br />
+
-
[[2lux]] - hCBP-1 (mutant) + Ca - NMR<br />
+
-
[[2lhl]], [[2lls]], [[2m3w]] – hCBP-1 (mutant) - NMR<br />
+
-
[[2llt]], [[2llu]] – hCBP-1 - NMR<br />
+
-
[[2jpt]] – bCBP-1 (mutant) – bovine - NMR <br />
+
-
''S100-A2''
+
**[[2rgi]] – hCBP-2<br />
 +
**[[4duq]] – hCBP-2 (mutant) + Ca <br />
-
[[2rgi]] – hCBP-2<br />
+
*S100-A3
-
[[4duq]] – hCBP-2 (mutant) + Ca <br />
+
-
''S100-A3''
+
**[[3psr]], [[3nsi]], [[3nso]] – hCBP-3 <br />
 +
**[[3nsk]], [[3nsl]] – hCBP-3 (mutant) <br />
-
[[3psr]], [[3nsi]], [[3nso]] – hCBP-3 <br />
+
*S100-A4 (Metastasin, Placental calcium-binding protein, Calvasculin)
-
[[3nsk]], [[3nsl]] – hCBP-3 (mutant) <br />
+
-
''S100-A4 (Metastasin, Placental calcium-binding protein, Calvasculin)''
+
**[[1m31]] – hCBP-4 - NMR <br />
 +
**[[2q91]] – hCBP-4 <br />
 +
**[[3c1v]], [[3cga]], [[3ko0]], [[4hsz]] – hCBP-4 + Ca <br />
 +
**[[3m0w]] – hCBP-4 + Ca + PCP<br />
 +
**[[3zwh]] – hCBP-4 (mutant) + Ca + myosin-9 peptide<br />
 +
**[[4eto]] – hCBP-4 + Ca + myosin-9 peptide<br />
 +
**[[2lnk]] – hCBP-4 + myosin-2a peptide - NMR<br />
-
[[1m31]] – hCBP-4 - NMR <br />
+
*S100-A5
-
[[2q91]] – hCBP-4 <br />
+
-
[[3c1v]], [[3cga]], [[3ko0]], [[4hsz]] – hCBP-4 + Ca <br />
+
-
[[3m0w]] – hCBP-4 + Ca + PCP<br />
+
-
[[3zwh]] – hCBP-4 (mutant) + Ca + myosin-9 peptide<br />
+
-
[[4eto]] – hCBP-4 + Ca + myosin-9 peptide<br />
+
-
[[2lnk]] – hCBP-4 + myosin-2a peptide - NMR<br />
+
-
''S100-A5''
+
**[[2kax]] – hCBP-5 - NMR <br />
 +
**[[4dir]] – hCBP-5 + Ca <br />
 +
**[[2kay]] – hCBP-5 + Ca - NMR <br />
-
[[2kax]] – hCBP-5 - NMR <br />
+
*S100-A6 (Calcyclin)
-
[[4dir]] – hCBP-5 + Ca <br />
+
-
[[2kay]] – hCBP-5 + Ca - NMR <br />
+
-
''S100-A6 (Calcyclin)''
+
**[[1cnp]], [[1a03]], [[2cnp]], [[1jwd]] – raCBP-6 – rabbit - NMR<br />
 +
**[[2jtt]] – raCBP-6 + calcyclin-binding protein - NMR<br />
 +
**[[1kso]], [[1k8u]], [[1k9p]] – hCBP-6 <br />
 +
**[[1k96]], [[1k9k]] – hCBP-6 + Ca <br />
-
[[1cnp]], [[1a03]], [[2cnp]], [[1jwd]] – raCBP-6 – rabbit - NMR<br />
+
*S100-A7 (Psoriasin)
-
[[2jtt]] – raCBP-6 + calcyclin-binding protein - NMR<br />
+
-
[[1kso]], [[1k8u]], [[1k9p]] – hCBP-6 <br />
+
-
[[1k96]], [[1k9k]] – hCBP-6 + Ca <br />
+
-
''S100-A7 (Psoriasin)''
+
**[[1psr]] – hCBP-7 + Ho <br />
 +
**[[2psr]], [[2wos]] – hCBP-7 + Zn + Ca <br />
 +
**[[2wnd]], [[4aqj]] – hCBP-7 (mutant) + Zn + Ca <br />
 +
**[[3psr]], [[2wor]] – hCBP-7 + Ca <br />
-
[[1psr]] – hCBP-7 + Ho <br />
+
*S100-A8 (Calgranulin-A; Migration inhibitory factor-related protein)
-
[[2psr]], [[2wos]] – hCBP-7 + Zn + Ca <br />
+
-
[[2wnd]], [[4aqj]] – hCBP-7 (mutant) + Zn + Ca <br />
+
-
[[3psr]], [[2wor]] – hCBP-7 + Ca <br />
+
-
''S100-A8 (Calgranulin-A; Migration inhibitory factor-related protein)''
+
**[[1mr8]] – hCBP-8 + Ca <br />
 +
**[[1irj]] – hCBP-9 + Ca <br />
 +
**[[1xk4]] – hCBP-8 (mutant) + Ca + hCBP-9 (mutant) <br />
 +
**[[4ggf]] – hCBP-8 + hCBP-9 + Ca + Mn <br />
-
[[1mr8]] – hCBP-8 + Ca <br />
+
*S100-A9 (Calgranulin-B or Migration inhibitory factor-related protein 14)
-
[[1irj]] – hCBP-9 + Ca <br />
+
-
[[1xk4]] – hCBP-8 (mutant) + Ca + hCBP-9 (mutant) <br />
+
-
[[4ggf]] – hCBP-8 + hCBP-9 + Ca + Mn <br />
+
-
''S100-A9 (Calgranulin-B or Migration inhibitory factor-related protein 14)''
+
**[[1xk4]] – hCPB-9 (mutant) + hCBP-8 (mutant) + Ca <br />
 +
**[[4ggf]] – hCPB-9 + hCBP-8 + Ca + Mn<br />
 +
**[[1irj]] – hCBP-9 + Ca <br />
-
[[1xk4]] – hCPB-9 (mutant) + hCBP-8 (mutant) + Ca <br />
+
*S100-A10 ( Calpaxin; P11)
-
[[4ggf]] – hCPB-9 + hCBP-8 + Ca + Mn<br />
+
-
[[1irj]] – hCBP-9 + Ca <br />
+
 +
**[[1a4p]] – hCBP-10 <br />
 +
**[[1bt6]] – hCBP-10 + annexin II <br />
 +
**[[4drw]], [[4hrg]] – hCBP-10/annexin II + AHNAK peptide<br />
 +
**[[4ftg]] – hCBP-10 + annexin II + AHNAK peptide<br />
 +
**[[4hre]], [[4hrh]] – hCBP-10 + annexin II + helicase-like transcription factor<br />
-
''S100-A10 ( Calpaxin; P11)''
+
*S100-A11 (Calgizzarin)
-
[[1a4p]] – hCBP-10 <br />
+
**[[1qls]] – CBP-11 + Ca + annexin I - pig <br />
-
[[1bt6]] – hCBP-10 + annexin II <br />
+
**[[1nsh]] – raCBP-11 - NMR<br />
-
[[4drw]], [[4hrg]] – hCBP-10/annexin II + AHNAK peptide<br />
+
**[[2luc]] – hCBP-11 - NMR<br />
-
[[4ftg]] – hCBP-10 + annexin II + AHNAK peptide<br />
+
**[[1v4z]], [[1v50]] – hCBP-11 N terminal - NMR<br />
-
[[4hre]], [[4hrh]] – hCBP-10 + annexin II + helicase-like transcription factor<br />
+
-
''S100-A11 (Calgizzarin)''
+
*S100-A12
-
[[1qls]] – CBP-11 + Ca + annexin I - pig <br />
+
**[[2wcf]] – hCBP-12<br />
-
[[1nsh]] – raCBP-11 - NMR<br />
+
**[[2m9g]] – hCBP-12 - NMR<br />
-
[[2luc]] – hCBP-11 - NMR<br />
+
**[[2wce]] – hCBP-12 (mutant) <br />
-
[[1v4z]], [[1v50]] – hCBP-11 N terminal - NMR<br />
+
**[[1e8a]], [[1gqm]] – hCBP-12 + Ca <br />
 +
**[[1odb]] – hCBP-12 + Cu + Ca <br />
 +
**[[2wc8]], [[2wcb]] – hCBP-12 + Zn <br />
-
''S100-A12''
+
*S100-A13
-
[[2wcf]] – hCBP-12<br />
+
**[[2cxj]] – CBP-13 – mouse - NMR<br />
-
[[2m9g]] – hCBP-12 - NMR<br />
+
**[[1yur]], [[1yus]] – hCBP-13 - NMR<br />
-
[[2wce]] – hCBP-12 (mutant) <br />
+
**[[1yut]], [[1yuu]] – hCBP-13 + Ca - NMR<br />
-
[[1e8a]], [[1gqm]] – hCBP-12 + Ca <br />
+
**[[2h2k]], [[2egd]] – hCBP-13 + Ca <br />
-
[[1odb]] – hCBP-12 + Cu + Ca <br />
+
**[[2k8m]] – hCBP-13 + peptide - NMR<br />
-
[[2wc8]], [[2wcb]] – hCBP-12 + Zn <br />
+
**[[2ki4]] – hCBP-13 + heparin-binding growth factor - NMR<br />
 +
**[[2ki6]] – hCBP-13 + heparin-binding growth factor + synaptotagmin-1- NMR<br />
 +
**[[2l5x]] – hCBP-13 + interleukin-1 α - NMR<br />
 +
**[[2le9]] – hCBP-13 + RAGEC2 - NMR<br />
 +
**[[2kot]] – hCBP-13 + amlexanox - NMR<br />
-
''S100-A13''
+
*S100-A14
-
[[2cxj]] – CBP-13 – mouse - NMR<br />
+
**[[2m0r]] – hCBP-14 - NMR<br />
-
[[1yur]], [[1yus]] – hCBP-13 - NMR<br />
+
-
[[1yut]], [[1yuu]] – hCBP-13 + Ca - NMR<br />
+
-
[[2h2k]], [[2egd]] – hCBP-13 + Ca <br />
+
-
[[2k8m]] – hCBP-13 + peptide - NMR<br />
+
-
[[2ki4]] – hCBP-13 + heparin-binding growth factor - NMR<br />
+
-
[[2ki6]] – hCBP-13 + heparin-binding growth factor + synaptotagmin-1- NMR<br />
+
-
[[2l5x]] – hCBP-13 + interleukin-1 α - NMR<br />
+
-
[[2le9]] – hCBP-13 + RAGEC2 - NMR<br />
+
-
[[2kot]] – hCBP-13 + amlexanox - NMR<br />
+
-
''S100-A14''
+
*S100-A15 (Koebnerisin or S100-A7A)
-
[[2m0r]] – hCBP-14 - NMR<br />
+
**[[4aqi]] – hCBP-15 + Ca + Zn<br />
-
''S100-A15 (Koebnerisin or S100-A7A)''
+
*S100-A16 (S100-F)
-
[[4aqi]] – hCBP-15 + Ca + Zn<br />
+
**[[2l50]] – hCBP-16 - NMR<br />
 +
**[[2l51]] – hCBP-16 + Ca - NMR<br />
 +
**[[3nxa]] – hCBP-16 <br />
-
''S100-A16 (S100-F)''
+
*S100B
-
[[2l50]] – hCBP-16 - NMR<br />
+
**[[1sym]], [[1b4c]] – rCBP – rat - NMR<br />
-
[[2l51]] – hCBP-16 + Ca - NMR<br />
+
**[[1qlk]], [[2k7o]] – rCBP + Ca - NMR<br />
-
[[3nxa]] – hCBP-16 <br />
+
**[[1xyd]] – rCBP + Zn + Ca - NMR<br />
 +
**[[1dt7]] – rCBP + Ca + p53 peptide - NMR<br />
 +
**[[1mwn]] – rCBP + F-actin capping protein peptide - NMR<br />
 +
**[[1mq1]] – hCBP + F-actin capping protein peptide - NMR<br />
 +
**[[3rm1]] – bCBP + F-actin capping protein peptide + Ca<br />
 +
**[[1psb]] – bCBP + NDR kinase peptide - NMR<br />
 +
**[[3iqq]] – bCBP + TRTK12 peptide <br />
 +
**[[1cfp]] – bCBP (mutant) - NMR <br />
 +
**[[1mho]], [[3cr4]], [[3gk1]], [[3gk2]], [[3gk4]], [[3iqo]], [[3lk0]], [[3lk1]], [[3lle]], [[3rlz]] – bCBP + Ca <br />
 +
**[[3cr2]], [[3cr5]] – bCBP + Zn + Ca <br />
 +
**[[4fqo]] – bCBP (mutant) + Ca + inhibitor<br />
 +
**[[1uwo]], [[2pru]] – hCBP - NMR <br />
 +
**[[2h61]], [[3hcm]] – hCBP + Ca <br />
 +
**[[3czt]], [[3d0y]], [[3d10]] – hCBP + Zn + Ca <br />
 +
**[[2m49]] – hCBP + fibroblast growth factor 2 - NMR<br />
-
===S100B===
+
*S100G (Calbindin)
-
[[1sym]], [[1b4c]] – rCBP – rat - NMR<br />
+
**[[3icb]] – bCBP + Ca <br />
-
[[1qlk]], [[2k7o]] – rCBP + Ca - NMR<br />
+
-
[[1xyd]] – rCBP + Zn + Ca - NMR<br />
+
-
[[1dt7]] – rCBP + Ca + p53 peptide - NMR<br />
+
-
[[1mwn]] – rCBP + F-actin capping protein peptide - NMR<br />
+
-
[[1mq1]] – hCBP + F-actin capping protein peptide - NMR<br />
+
-
[[3rm1]] – bCBP + F-actin capping protein peptide + Ca<br />
+
-
[[1psb]] – bCBP + NDR kinase peptide - NMR<br />
+
-
[[3iqq]] – bCBP + TRTK12 peptide <br />
+
-
[[1cfp]] – bCBP (mutant) - NMR <br />
+
-
[[1mho]], [[3cr4]], [[3gk1]], [[3gk2]], [[3gk4]], [[3iqo]], [[3lk0]], [[3lk1]], [[3lle]], [[3rlz]] – bCBP + Ca <br />
+
-
[[3cr2]], [[3cr5]] – bCBP + Zn + Ca <br />
+
-
[[4fqo]] – bCBP (mutant) + Ca + inhibitor<br />
+
-
[[1uwo]], [[2pru]] – hCBP - NMR <br />
+
-
[[2h61]], [[3hcm]] – hCBP + Ca <br />
+
-
[[3czt]], [[3d0y]], [[3d10]] – hCBP + Zn + Ca <br />
+
-
[[2m49]] – hCBP + fibroblast growth factor 2 - NMR<br />
+
-
===S100G (Calbindin)===
+
*Calbindin D9k
-
[[3icb]] – bCBP + Ca <br />
+
**[[1clb]] – bCBP - NMR<br />
 +
**[[1cdn]], [[1bod]], [[1d1o]] – bCBP (mutant) - NMR <br />
 +
**[[4icb]] – bCBP + Ca <br />
 +
**[[1ig5]] – bCBP + Mg <br />
 +
**[[1igv]] – bCBP + Mn <br />
 +
**[[1boc]], [[2bca]], [[2bcb]] – bCBP - NMR <br />
 +
**[[1ht9]] – bCBP (mutant) + Ca <br />
 +
**[[1qx2]] – bCBP (mutant) + Zn + Ca<br />
 +
**[[1b1g]] – bCBP (mutant) + Ca - NMR <br />
 +
**[[1kqv]], [[1ksm]], [[1n65]] – bCBP (mutant) + Lanthanide - NMR <br />
 +
**[[1kcy]], [[2maz]] – bCBP (mutant) - NMR <br />
 +
**[[1cb1]] – CBP – pig - NMR <br />
-
''Calbindin D9k''
+
*S100P
-
[[1clb]] – bCBP - NMR<br />
+
**[[1j55]] – hCBP + Ca <br />
-
[[1cdn]], [[1bod]], [[1d1o]] – bCBP (mutant) - NMR <br />
+
**[[1ozo]] – hCBP - NMR<br />
-
[[4icb]] – bCBP + Ca <br />
+
-
[[1ig5]] – bCBP + Mg <br />
+
-
[[1igv]] – bCBP + Mn <br />
+
-
[[1boc]], [[2bca]], [[2bcb]] – bCBP - NMR <br />
+
-
[[1ht9]] – bCBP (mutant) + Ca <br />
+
-
[[1qx2]] – bCBP (mutant) + Zn + Ca<br />
+
-
[[1b1g]] – bCBP (mutant) + Ca - NMR <br />
+
-
[[1kqv]], [[1ksm]], [[1n65]] – bCBP (mutant) + Lanthanide - NMR <br />
+
-
[[1kcy]], [[2maz]] – bCBP (mutant) - NMR <br />
+
-
[[1cb1]] – CBP – pig - NMR <br />
+
-
===S100P===
+
*S100Z
-
[[1j55]] – hCBP + Ca <br />
+
**[[2y5i]] – CBP + Ca - zebrafish <br />
-
[[1ozo]] – hCBP - NMR<br />
+
}}
-
 
+
-
===S100Z===
+
-
 
+
-
[[2y5i]] – CBP + Ca - zebrafish <br />
+
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:58, 9 December 2014

Template:STRUCTURE 4eto

S100 proteins are calcium-binding proteins (CBP) found in vertebrates and contain 2 helix-loop-helix calcium binding sites. S100 name is derived from their being 100% soluble in ammonium sulfate. There are at least 21 S100 proteins. Most S100 proteins undergo conformational change upon calcium binding.
S100-A1 is a regulator of myocardial contractility.
S100-A2 may have a tumor suppression function.
S100-A4 and S100-A11 may function in motility, invasion and tubulin polymerization.
S100-A6 may function in calcium-dependent insulin release.
S100-A7 is an antimicrobial peptide mainly against E. coli.
S100-A8 combined with S100-A9 (calprotectin) may function in the inhibition of casein kinase and regulate inflammatory processes.
S100-A10 is implicated in the transport of neurotransmitters.
S100-A12 and S100-A13 may function in calcium-dependent signal transduction pathways.
S100-A15 is found in psoriatic skin and functions as antimicrobial peptide.
S100B levels increase in patients suffering from brain damage and are used as diagnostics for traumatic head injury.
S100G is vitamin-D dependent calcium-binding protein and is called calbindin D9k and calbindin D28k depending on its molecular weight. S100G mediates the transport of calcium across enterocytes.

3D Structures of S100 proteins

Updated on 09-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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