3ons
From Proteopedia
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| - | [[ | + | ==Crystal structure of Human Ubiquitin in a new crystal form== |
| + | <StructureSection load='3ons' size='340' side='right' caption='[[3ons]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3ons]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ONS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ONS FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UBB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ons FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ons OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ons RCSB], [http://www.ebi.ac.uk/pdbsum/3ons PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | A new crystal structure of human ubiquitin is reported at 1.8 A resolution. Compared with the other known crystal structure or the solution NMR structure of monomeric human ubiquitin, this new structure is similar in its overall fold but differs with respect to the conformation of the backbone in a surface-exposed region. The conformation reported here resembles conformations previously seen in complex with deubiquinating enzymes, wherein the Asp52/Gly53 main chain and Glu24 side chain move. This movement exposes the backbone carbonyl of Asp52 to the exterior of the molecule, making it possible to engage in hydrogen-bond contacts with neighboring molecules, rather than in an internal hydrogen bond with the backbone of Glu24. This particular crystal form of ubiquitin has been used in a large number of solid state NMR studies. The structure described here elucidates the origin of many of the chemical shift differences comparing solution and solid state studies. | ||
| - | + | The structure of human ubiquitin in 2-methyl-2,4-pentanediol: a new conformational switch.,Huang KY, Amodeo GA, Tong L, McDermott A Protein Sci. 2011 Mar;20(3):630-9. doi: 10.1002/pro.584. PMID:21432937<ref>PMID:21432937</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Ubiquitin|Ubiquitin]] | *[[Ubiquitin|Ubiquitin]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Amodeo, G A | + | [[Category: Amodeo, G A]] |
| - | [[Category: Huang, K Y | + | [[Category: Huang, K Y]] |
| - | [[Category: Mcdermott, A E | + | [[Category: Mcdermott, A E]] |
| - | [[Category: Tong, L | + | [[Category: Tong, L]] |
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
[[Category: Ubiquitin fold]] | [[Category: Ubiquitin fold]] | ||
Revision as of 12:02, 9 December 2014
Crystal structure of Human Ubiquitin in a new crystal form
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