3ory
From Proteopedia
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| - | [[ | + | ==Crystal structure of Flap endonuclease 1 from hyperthermophilic archaeon Desulfurococcus amylolyticus== |
| + | <StructureSection load='3ory' size='340' side='right' caption='[[3ory]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3ory]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Desulfurococcus_amylolyticus Desulfurococcus amylolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ORY FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ory FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ory OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ory RCSB], [http://www.ebi.ac.uk/pdbsum/3ory PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Flap endonuclease 1 (FEN1) is a key enzyme in DNA repair and DNA replication. It is a structure-specific nuclease that removes 5'-overhanging flaps and the RNA/DNA primer during maturation of the Okazaki fragment. Homologues of FEN1 exist in a wide range of bacteria, archaea and eukaryotes. In order to further understand the structural basis of the DNA recognition, binding and cleavage mechanism of FEN1, the structure of FEN1 from the hyperthermophilic archaeon Desulfurococcus amylolyticus (DaFEN1) was determined at 2.00 A resolution. The overall fold of DaFEN1 was similar to those of other archaeal FEN1 proteins; however, the helical clamp and the flexible loop exhibited a putative substrate-binding pocket with a unique conformation. | ||
| - | + | Structure of flap endonuclease 1 from the hyperthermophilic archaeon Desulfurococcus amylolyticus.,Mase T, Kubota K, Miyazono K, Kawarabayasi Y, Tanokura M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Feb 1;67(Pt, 2):209-13. Epub 2011 Jan 21. PMID:21301087<ref>PMID:21301087</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Endonuclease|Endonuclease]] | *[[Endonuclease|Endonuclease]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Desulfurococcus amylolyticus]] | [[Category: Desulfurococcus amylolyticus]] | ||
| - | [[Category: Kawarabayashii, Y | + | [[Category: Kawarabayashii, Y]] |
| - | [[Category: Kubota, K | + | [[Category: Kubota, K]] |
| - | [[Category: Mase, T | + | [[Category: Mase, T]] |
| - | [[Category: Miyazono, K | + | [[Category: Miyazono, K]] |
| - | [[Category: Tanokura, M | + | [[Category: Tanokura, M]] |
[[Category: Endonuclease]] | [[Category: Endonuclease]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 12:10, 9 December 2014
Crystal structure of Flap endonuclease 1 from hyperthermophilic archaeon Desulfurococcus amylolyticus
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