3rjr

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[[Image:3rjr.png|left|200px]]
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==Crystal Structure of pro-TGF beta 1==
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<StructureSection load='3rjr' size='340' side='right' caption='[[3rjr]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rjr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RJR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TGFB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 Sus scrofa])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rjr RCSB], [http://www.ebi.ac.uk/pdbsum/3rjr PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Transforming growth factor (TGF)-beta is stored in the extracellular matrix as a latent complex with its prodomain. Activation of TGF-beta1 requires the binding of alpha(v) integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-beta binding proteins. Crystals of dimeric porcine proTGF-beta1 reveal a ring-shaped complex, a novel fold for the prodomain, and show how the prodomain shields the growth factor from recognition by receptors and alters its conformation. Complex formation between alpha(v)beta(6) integrin and the prodomain is insufficient for TGF-beta1 release. Force-dependent activation requires unfastening of a 'straitjacket' that encircles each growth-factor monomer at a position that can be locked by a disulphide bond. Sequences of all 33 TGF-beta family members indicate a similar prodomain fold. The structure provides insights into the regulation of a family of growth and differentiation factors of fundamental importance in morphogenesis and homeostasis.
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{{STRUCTURE_3rjr| PDB=3rjr | SCENE= }}
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Latent TGF-beta structure and activation.,Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, Springer TA Nature. 2011 Jun 15;474(7351):343-9. doi: 10.1038/nature10152. PMID:21677751<ref>PMID:21677751</ref>
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===Crystal Structure of pro-TGF beta 1===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_21677751}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3rjr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RJR OCA].
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</StructureSection>
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Shi, M L.]]
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[[Category: Shi, M L]]
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[[Category: Springer, T A.]]
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[[Category: Springer, T A]]
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[[Category: Zhu, J H.]]
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[[Category: Zhu, J H]]
[[Category: Activation]]
[[Category: Activation]]
[[Category: Cytokine]]
[[Category: Cytokine]]
[[Category: Integrin]]
[[Category: Integrin]]
[[Category: Tgf beta]]
[[Category: Tgf beta]]

Revision as of 12:17, 9 December 2014

Crystal Structure of pro-TGF beta 1

3rjr, resolution 3.05Å

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