1ngt
From Proteopedia
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| - | [[Image:1ngt.gif|left|200px]] | + | [[Image:1ngt.gif|left|200px]] |
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| - | '''The Role of Minor Groove Functional Groups in DNA Hydration''' | + | {{Structure |
| + | |PDB= 1ngt |SIZE=350|CAPTION= <scene name='initialview01'>1ngt</scene>, resolution 2.04Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''The Role of Minor Groove Functional Groups in DNA Hydration''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1NGT is a [ | + | 1NGT is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGT OCA]. |
==Reference== | ==Reference== | ||
| - | The role of minor groove functional groups in DNA hydration., Woods KK, Lan T, McLaughlin LW, Williams LD, Nucleic Acids Res. 2003 Mar 1;31(5):1536-40. PMID:[http:// | + | The role of minor groove functional groups in DNA hydration., Woods KK, Lan T, McLaughlin LW, Williams LD, Nucleic Acids Res. 2003 Mar 1;31(5):1536-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12595562 12595562] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Lan, T.]] | [[Category: Lan, T.]] | ||
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[[Category: spine of hydration]] | [[Category: spine of hydration]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:56:41 2008'' |
Revision as of 10:56, 20 March 2008
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| , resolution 2.04Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
The Role of Minor Groove Functional Groups in DNA Hydration
Overview
Here we describe the crystal structure of modified [d(CGCGAATTCGCG)]2 refined to 2.04 A. The modification, which affects only the two thymines at the central ApT step, involves isosteric removal of the 2-keto oxygen atoms and substitution of the N1 nitrogen with carbon. The crystal structure reveals the ability of this modified thymine to effectively base pair with adenine in [d(CGCGAAtTCGCG)]2. The structure also suggests that the minor groove 'spine of hydration' is destabilized but essentially intact.
About this Structure
1NGT is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
The role of minor groove functional groups in DNA hydration., Woods KK, Lan T, McLaughlin LW, Williams LD, Nucleic Acids Res. 2003 Mar 1;31(5):1536-40. PMID:12595562
Page seeded by OCA on Thu Mar 20 12:56:41 2008
