3pmv
From Proteopedia
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| - | [[ | + | ==Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator== |
| + | <StructureSection load='3pmv' size='340' side='right' caption='[[3pmv]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3pmv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PMV FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=557:N-[(2S)-2-{4-[4-(HYDROXYMETHYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]PHENYL}PROPYL]PROPANE-2-SULFONAMIDE'>557</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3o28|3o28]], [[3o29|3o29]], [[3o2a|3o2a]], [[3o6g|3o6g]], [[3o6h|3o6h]], [[3o6i|3o6i]], [[3pmw|3pmw]], [[3pmx|3pmx]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Gria2, Glur2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pmv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pmv RCSB], [http://www.ebi.ac.uk/pdbsum/3pmv PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotype with a promising overall profile, exemplified by 19. | ||
| - | + | Structure based evolution of a novel series of positive modulators of the AMPA receptor.,Jamieson C, Maclean JK, Brown CI, Campbell RA, Gillen KJ, Gillespie J, Kazemier B, Kiczun M, Lamont Y, Lyons AJ, Moir EM, Morrow JA, Pantling J, Rankovic Z, Smith L Bioorg Med Chem Lett. 2011 Jan 15;21(2):805-11. Epub 2010 Nov 25. PMID:21190850<ref>PMID:21190850</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Ionotropic Glutamate Receptors|Ionotropic Glutamate Receptors]] | *[[Ionotropic Glutamate Receptors|Ionotropic Glutamate Receptors]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Brown, C I | + | [[Category: Brown, C I]] |
| - | [[Category: Campbell, R A | + | [[Category: Campbell, R A]] |
| - | [[Category: Gillen, K J | + | [[Category: Gillen, K J]] |
| - | [[Category: Gillespie, J | + | [[Category: Gillespie, J]] |
| - | [[Category: Jamieson, C | + | [[Category: Jamieson, C]] |
| - | [[Category: Kazemier, B | + | [[Category: Kazemier, B]] |
| - | [[Category: Kiczun, M | + | [[Category: Kiczun, M]] |
| - | [[Category: Lamont, Y | + | [[Category: Lamont, Y]] |
| - | [[Category: Lyons, A J | + | [[Category: Lyons, A J]] |
| - | [[Category: Maclean, J K.F | + | [[Category: Maclean, J K.F]] |
| - | [[Category: Moir, E M | + | [[Category: Moir, E M]] |
| - | [[Category: Morrow, J A | + | [[Category: Morrow, J A]] |
| - | [[Category: Pantling, J | + | [[Category: Pantling, J]] |
| - | [[Category: Rankovic, Z | + | [[Category: Rankovic, Z]] |
| - | [[Category: Smith, L | + | [[Category: Smith, L]] |
[[Category: Chimera protein]] | [[Category: Chimera protein]] | ||
[[Category: Fusion protein]] | [[Category: Fusion protein]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Revision as of 12:46, 9 December 2014
Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator
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Categories: Rattus norvegicus | Brown, C I | Campbell, R A | Gillen, K J | Gillespie, J | Jamieson, C | Kazemier, B | Kiczun, M | Lamont, Y | Lyons, A J | Maclean, J K.F | Moir, E M | Morrow, J A | Pantling, J | Rankovic, Z | Smith, L | Chimera protein | Fusion protein | Membrane protein | Transport protein
