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1njr

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[[Image:1njr.gif|left|200px]]<br /><applet load="1njr" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1njr.gif|left|200px]]
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caption="1njr, resolution 1.9&Aring;" />
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'''Crystal structure of yeast ymx7, an ADP-ribose-1''-monophosphatase'''<br />
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{{Structure
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|PDB= 1njr |SIZE=350|CAPTION= <scene name='initialview01'>1njr</scene>, resolution 1.9&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=XYL:D-XYLITOL'>XYL</scene>
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|ACTIVITY=
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|GENE= YMR087W or YM9582.12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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}}
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'''Crystal structure of yeast ymx7, an ADP-ribose-1''-monophosphatase'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1NJR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=XYL:'>XYL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NJR OCA].
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1NJR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NJR OCA].
==Reference==
==Reference==
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Structure and mechanism of ADP-ribose-1''-monophosphatase (Appr-1''-pase), a ubiquitous cellular processing enzyme., Kumaran D, Eswaramoorthy S, Studier FW, Swaminathan S, Protein Sci. 2005 Mar;14(3):719-26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15722447 15722447]
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Structure and mechanism of ADP-ribose-1''-monophosphatase (Appr-1''-pase), a ubiquitous cellular processing enzyme., Kumaran D, Eswaramoorthy S, Studier FW, Swaminathan S, Protein Sci. 2005 Mar;14(3):719-26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15722447 15722447]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: protein structure initiative]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: psi]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
[[Category: two domain organization]]
[[Category: two domain organization]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:06:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:57:48 2008''

Revision as of 10:57, 20 March 2008

Image:1njr.gif


PDB ID 1njr

Drag the structure with the mouse to rotate
, resolution 1.9Å
Ligands:
Gene: YMR087W or YM9582.12 (Saccharomyces cerevisiae)
Coordinates: save as pdb, mmCIF, xml



Crystal structure of yeast ymx7, an ADP-ribose-1-monophosphatase


Overview

Appr-1-pase, an important and ubiquitous cellular processing enzyme involved in the tRNA splicing pathway, catalyzes the conversion of ADP-ribose-1monophosphate (Appr-1-p) to ADP-ribose. The structures of the native enzyme from the yeast and its complex with ADP-ribose were determined to 1.9 A and 2.05 A, respectively. Analysis of the three-dimensional structure of this protein, selected as a target in a structural genomics project, reveals its putative function and provides clues to the catalytic mechanism. The structure of the 284-amino acid protein shows a two-domain architecture consisting of a three-layer alphabetaalpha sandwich N-terminal domain connected to a small C-terminal helical domain. The structure of Appr-1-pase in complex with the product, ADP-ribose, reveals an active-site water molecule poised for nucleophilic attack on the terminal phosphate group. Loop-region residues Asn 80, Asp 90, and His 145 may form a catalytic triad.

About this Structure

1NJR is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of ADP-ribose-1-monophosphatase (Appr-1-pase), a ubiquitous cellular processing enzyme., Kumaran D, Eswaramoorthy S, Studier FW, Swaminathan S, Protein Sci. 2005 Mar;14(3):719-26. PMID:15722447

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