3san
From Proteopedia
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| - | [[ | + | ==Crystal structure of influenza A virus neuraminidase N5 complexed with Zanamivir== |
| + | <StructureSection load='3san' size='340' side='right' caption='[[3san]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3san]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SAN FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nss|3nss]], [[3sal|3sal]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11320 Influenza A virus])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3san FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3san OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3san RCSB], [http://www.ebi.ac.uk/pdbsum/3san PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | There are 9 serotypes of neuraminidase (NA) from influenza A virus (N1 to N9), which are classified into two groups based on primary sequences (groups 1 and 2). The structural hallmark of the two groups is the presence or absence of an extra 150-cavity (formed by the 150-loop) in the active site. Thus far, structures of NAs from 6 out of the 9 serotypes have been solved. Here, we solved the N5 structure, the last unknown structure group 1 serotype with a unique Asn147 residue in its 150-loop, demonstrating that it has an extended 150-cavity that closes upon inhibitor binding. | ||
| - | + | Influenza a virus n5 neuraminidase has an extended 150-cavity.,Wang M, Qi J, Liu Y, Vavricka CJ, Wu Y, Li Q, Gao GF J Virol. 2011 Aug;85(16):8431-5. Epub 2011 Jun 8. PMID:21653672<ref>PMID:21653672</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Neuraminidase|Neuraminidase]] | *[[Neuraminidase|Neuraminidase]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Exo-alpha-sialidase]] | [[Category: Exo-alpha-sialidase]] | ||
[[Category: Influenza a virus]] | [[Category: Influenza a virus]] | ||
| - | [[Category: Gao, G F | + | [[Category: Gao, G F]] |
| - | [[Category: Li, Q | + | [[Category: Li, Q]] |
| - | [[Category: Liu, Y | + | [[Category: Liu, Y]] |
| - | [[Category: Qi, J X | + | [[Category: Qi, J X]] |
| - | [[Category: Vavricka, C J | + | [[Category: Vavricka, C J]] |
| - | [[Category: Wang, M Y | + | [[Category: Wang, M Y]] |
| - | [[Category: Wu, Y | + | [[Category: Wu, Y]] |
[[Category: 6-bladed beta-propeller]] | [[Category: 6-bladed beta-propeller]] | ||
[[Category: Calcium binding]] | [[Category: Calcium binding]] | ||
Revision as of 13:23, 9 December 2014
Crystal structure of influenza A virus neuraminidase N5 complexed with Zanamivir
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