3nr6
From Proteopedia
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| - | [[ | + | ==Crystal structure of xenotropic murine leukemia virus-related virus (XMRV) protease== |
| + | <StructureSection load='3nr6' size='340' side='right' caption='[[3nr6]], [[Resolution|resolution]] 1.97Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3nr6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NR6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NR6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2hvp|2hvp]], [[4fiv|4fiv]], [[2fmb|2fmb]], [[2i1a|2i1a]], [[2rsp|2rsp]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10239 Viruses])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nr6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nr6 RCSB], [http://www.ebi.ac.uk/pdbsum/3nr6 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Using energy and density guided Rosetta refinement to improve molecular replacement, we determined the crystal structure of the protease encoded by xenotropic murine leukemia virus-related virus (XMRV). Despite overall similarity of XMRV protease to other retropepsins, the topology of its dimer interface more closely resembles those of the monomeric, pepsin-like enzymes. Thus, XMRV protease may represent a distinct branch of the aspartic protease family. | ||
| - | + | Crystal structure of XMRV protease differs from the structures of other retropepsins.,Li M, Dimaio F, Zhou D, Gustchina A, Lubkowski J, Dauter Z, Baker D, Wlodawer A Nat Struct Mol Biol. 2011 Jan 23. PMID:21258323<ref>PMID:21258323</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Virus protease|Virus protease]] | *[[Virus protease|Virus protease]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Viruses]] | [[Category: Viruses]] | ||
| - | [[Category: Dauter, Z | + | [[Category: Dauter, Z]] |
| - | [[Category: Gustchina, A | + | [[Category: Gustchina, A]] |
| - | [[Category: Li, M | + | [[Category: Li, M]] |
| - | [[Category: Lubkowski, J | + | [[Category: Lubkowski, J]] |
| - | [[Category: Wlodawer, A | + | [[Category: Wlodawer, A]] |
| - | [[Category: Zhou, D | + | [[Category: Zhou, D]] |
[[Category: Dimer]] | [[Category: Dimer]] | ||
[[Category: Hydrolase-inhibitor complex]] | [[Category: Hydrolase-inhibitor complex]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
Revision as of 13:25, 9 December 2014
Crystal structure of xenotropic murine leukemia virus-related virus (XMRV) protease
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Categories: Viruses | Dauter, Z | Gustchina, A | Li, M | Lubkowski, J | Wlodawer, A | Zhou, D | Dimer | Hydrolase-inhibitor complex | Protease
