3okj
From Proteopedia
(Difference between revisions)
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| - | + | ==Alpha-keto-aldehyde binding mechanism reveals a novel lead structure motif for proteasome inhibition== | |
| - | + | <StructureSection load='3okj' size='340' side='right' caption='[[3okj]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3okj]] is a 28 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OKJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EP9:N-[(BENZYLOXY)CARBONYL]-L-LEUCYL-N-[(2S,3S)-3-HYDROXY-1-(4-HYDROXYPHENYL)-4-OXOBUTAN-2-YL]-L-LEUCINAMIDE'>EP9</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ryp|1ryp]], [[1j2q|1j2q]], [[3d29|3d29]], [[1g65|1g65]]</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3okj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3okj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3okj RCSB], [http://www.ebi.ac.uk/pdbsum/3okj PDBsum]</span></td></tr> |
| - | [[3okj]] is a 28 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OKJ OCA]. | + | </table> |
==See Also== | ==See Also== | ||
*[[Proteasome|Proteasome]] | *[[Proteasome|Proteasome]] | ||
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
[[Category: Proteasome endopeptidase complex]] | [[Category: Proteasome endopeptidase complex]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Gallastegui, P | + | [[Category: Gallastegui, P]] |
| - | [[Category: Groll, M | + | [[Category: Groll, M]] |
| - | [[Category: Huber, R | + | [[Category: Huber, R]] |
| - | [[Category: Kloetzel, PM | + | [[Category: Kloetzel, PM]] |
| - | [[Category: Poynor, M | + | [[Category: Poynor, M]] |
| - | [[Category: Schmidt, B | + | [[Category: Schmidt, B]] |
| - | [[Category: Stein, M | + | [[Category: Stein, M]] |
[[Category: Central antiparallel beta-sheet flanked by helice]] | [[Category: Central antiparallel beta-sheet flanked by helice]] | ||
[[Category: Cytosol]] | [[Category: Cytosol]] | ||
Revision as of 13:27, 9 December 2014
Alpha-keto-aldehyde binding mechanism reveals a novel lead structure motif for proteasome inhibition
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Categories: Proteasome endopeptidase complex | Saccharomyces cerevisiae | Gallastegui, P | Groll, M | Huber, R | Kloetzel, PM | Poynor, M | Schmidt, B | Stein, M | Central antiparallel beta-sheet flanked by helice | Cytosol | Hydrolase-hydrolase inhibitor complex | Inhibitor | Nucleus | Protease | Turnover of ubiquitinated substrate | Ubiquitin
